Inflammatory Adaptation in Barrier Tissues

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2021 Jun 25

PMID 34171319

Citations 32

Authors

Rachel E Niec

Alexander Y Rudensky

Elaine Fuchs

Affiliations

Soon will be listed here.

Abstract

Surface epithelia provide a critical barrier to the outside world. Upon a barrier breach, resident epithelial and immune cells coordinate efforts to control infections and heal tissue damage. Inflammation can etch lasting marks within tissues, altering features such as scope and quality of future responses. By remembering inflammatory experiences, tissues are better equipped to quickly and robustly respond to barrier breaches. Alarmingly, in disease states, memory may fuel the inflammatory fire. Here, we review the cellular communication networks in barrier tissues and the integration between tissue-resident and recruited immune cells and tissue stem cells underlying tissue adaptation to environmental stress.

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