CXCL12/CXCR4 Facilitates Perineural Invasion Via Induction of the Twist/S100A4 Axis in Salivary Adenoid Cystic Carcinoma

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2021 Jun 25

PMID 34170080

Citations 4

Authors

Mei Zhang

Min Zheng

Li Dai

Wei-Long Zhang

Hua-Yang Fan

Xiang-Hua Yu

Xin Pang

Peng Liao

Bing-Jun Chen

Sha-Sha Wang

Ming-Xin Cao

Xiang-Rui Ma

Xin-Hua Liang

Ya-Ling Tang

Affiliations

Soon will be listed here.

Abstract

The activation of CXCL12/CXCR4 axis participated in the progression of multiple cancers, but potential effect in terms of perineural invasion (PNI) in SACC remained ambiguous. In this study, we identified that CXCL12 substantially expressed in nerve cells. CXCR4 strikingly expressed in tumour cells, and CXCR4 expression was closely associated with the level of EMT-associated proteins and Schwann cell hallmarks at nerve invasion frontier in SACC. Activation of CXCL12/CXCR4 axis could promote PNI and up-regulate relative genes of EMT and Schwann cell hallmarks both in vitro and in vivo, which could be inhibited by Twist silence. After overexpressing S100A4, the impaired PNI ability of SACC cells induced by Twist knockdown was significantly reversed, and pseudo foot was visualized frequently. Collectively, the results indicated that CXCL12/CXCR4 might promote PNI by provoking the tumour cell to differentiate towards Schwann-like cell through Twist/S100A4 axis in SACC.

Citing Articles

Apolipoprotein D is crucial for promoting perineural invasion in salivary adenoid cystic carcinoma.

Huang G, Chen S, Han B, Zhang G, Bao M, Lubamba G Br J Cancer. 2025; .

PMID: 39962257 DOI: 10.1038/s41416-025-02946-1.

Unraveling the Role of Epithelial-Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review.

Hoch C, Stogbauer F, Wollenberg B Cancers (Basel). 2023; 15(11).

PMID: 37296849 PMC: 10252036. DOI: 10.3390/cancers15112886.

Transcriptomic insights into adenoid cystic carcinoma via RNA sequencing.

Tang Y, An P, Gu B, Yi S, Hu X, Wu W Front Genet. 2023; 14:1144945.

PMID: 37152992 PMC: 10160386. DOI: 10.3389/fgene.2023.1144945.

The GAL/GALR2 axis promotes the perineural invasion of salivary adenoid cystic carcinoma via epithelial-to-mesenchymal transition.

Wang J, Yang Z, Liu Y, Li H, Yang X, Gao W Cancer Med. 2022; 12(4):4496-4509.

PMID: 36039037 PMC: 9972115. DOI: 10.1002/cam4.5181.

CXCL12/CXCR4 facilitates perineural invasion via induction of the Twist/S100A4 axis in salivary adenoid cystic carcinoma.

Zhang M, Zheng M, Dai L, Zhang W, Fan H, Yu X J Cell Mol Med. 2021; 25(16):7901-7912.

PMID: 34170080 PMC: 8358865. DOI: 10.1111/jcmm.16713.

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