Unraveling the Role of Epithelial-Mesenchymal Transition in Adenoid Cystic Carcinoma of the Salivary Glands: A Comprehensive Review

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2023 Jun 10

PMID 37296849

Authors

Cosima C Hoch

Fabian Stogbauer

Barbara Wollenberg

Affiliations

Soon will be listed here.

Abstract

Salivary adenoid cystic carcinoma (SACC) is considered a challenging malignancy; it is characterized by a slow-growing nature, yet a high risk of recurrence and distant metastasis, presenting significant hurdles in its treatment and management. At present, there are no approved targeted agents available for the management of SACC and systemic chemotherapy protocols that have demonstrated efficacy remain to be elucidated. Epithelial-mesenchymal transition (EMT) is a complex process that is closely associated with tumor progression and metastasis, enabling epithelial cells to acquire mesenchymal properties, including increased mobility and invasiveness. Several molecular signaling pathways have been implicated in the regulation of EMT in SACC, and understanding these mechanisms is crucial to identifying new therapeutic targets and developing more effective treatment approaches. This manuscript aims to provide a comprehensive overview of the latest research on the role of EMT in SACC, including the molecular pathways and biomarkers involved in EMT regulation. By highlighting the most recent findings, this review offers insights into potential new therapeutic strategies that could improve the management of SACC patients, especially those with recurrent or metastatic disease.

Citing Articles

Effect of silencing Ras homolog family member C on proliferation, invasion, and migration of salivary adenoid cystic carcinoma.

Yu W, Zhao P, Shao Y, Xu Y, Xu J, Xie L Hua Xi Kou Qiang Yi Xue Za Zhi. 2024; 42(6):723-734.

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References

de Freitas Silva B, Yamamoto-Silva F, Pontes H, Dos Santos Pinto Junior D . E-cadherin downregulation and Twist overexpression since early stages of oral carcinogenesis. J Oral Pathol Med. 2013; 43(2):125-31. DOI: 10.1111/jop.12096. View

Cantu G . Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: from aetiopathogenesis to diagnosis. Acta Otorhinolaryngol Ital. 2021; 41(3):206-214. PMC: 8283400. DOI: 10.14639/0392-100X-N1379. View

Denaro M, Navari E, Ugolini C, Seccia V, Donati V, Casani A . A microRNA signature for the differential diagnosis of salivary gland tumors. PLoS One. 2019; 14(1):e0210968. PMC: 6347363. DOI: 10.1371/journal.pone.0210968. View

Xu L, Zhao F, Yang W, Chen C, Du Z, Fu M . MYB promotes the growth and metastasis of salivary adenoid cystic carcinoma. Int J Oncol. 2019; 54(5):1579-1590. PMC: 6438425. DOI: 10.3892/ijo.2019.4754. View

Chae Y, Chung S, Davis A, Carneiro B, Chandra S, Kaplan J . Adenoid cystic carcinoma: current therapy and potential therapeutic advances based on genomic profiling. Oncotarget. 2015; 6(35):37117-34. PMC: 4741919. DOI: 10.18632/oncotarget.5076. View

Yang L, Wang T, Zhang J, Liu Z, Wang X . Expression of BTBD7 in primary salivary adenoid cystic carcinoma and correlation with Slug and prognosis. Cancer Biomark. 2016; 17(2):179-85. DOI: 10.3233/CBM-160629. View

Slack J, Tosh D . Transdifferentiation and metaplasia--switching cell types. Curr Opin Genet Dev. 2001; 11(5):581-6. DOI: 10.1016/s0959-437x(00)00236-7. View

Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J . The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol. 2000; 2(2):84-9. DOI: 10.1038/35000034. View

Yuen H, Chua C, Chan Y, Wong Y, Wang X, Chan K . Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer. Histopathology. 2007; 50(5):648-58. DOI: 10.1111/j.1365-2559.2007.02665.x. View

10.

Bommi P, Ravindran S, Raychaudhuri P, Bagchi S . DDB2 regulates Epithelial-to-Mesenchymal Transition (EMT) in Oral/Head and Neck Squamous Cell Carcinoma. Oncotarget. 2018; 9(78):34708-34718. PMC: 6205178. DOI: 10.18632/oncotarget.26168. View

11.

Jiang Y, Feng X, Zheng L, Li S, Ge X, Zhang J . Thioredoxin 1 mediates TGF-β-induced epithelial-mesenchymal transition in salivary adenoid cystic carcinoma. Oncotarget. 2015; 6(28):25506-19. PMC: 4694848. DOI: 10.18632/oncotarget.4635. View

12.

Chen Y, Wang K, Qian C, Leach R . DNA methylation is associated with transcription of Snail and Slug genes. Biochem Biophys Res Commun. 2012; 430(3):1083-90. PMC: 3552036. DOI: 10.1016/j.bbrc.2012.12.034. View

13.

Locati L, Galbiati D, Calareso G, Alfieri S, Singer S, Cavalieri S . Patients with adenoid cystic carcinomas of the salivary glands treated with lenvatinib: Activity and quality of life. Cancer. 2020; 126(9):1888-1894. DOI: 10.1002/cncr.32754. View

14.

Dong L, Wang Y, Li S, Yu G, Gan Y, Li D . TGF-beta1 promotes migration and invasion of salivary adenoid cystic carcinoma. J Dent Res. 2011; 90(6):804-9. DOI: 10.1177/0022034511401407. View

15.

West R, Kong C, Clarke N, Gilks T, Lipsick J, Cao H . MYB expression and translocation in adenoid cystic carcinomas and other salivary gland tumors with clinicopathologic correlation. Am J Surg Pathol. 2010; 35(1):92-9. PMC: 3127258. DOI: 10.1097/PAS.0b013e3182002777. View

16.

Wu B, Wei J, Hu Z, Shan C, Wang L, Zhang C . Slug silencing inhibited perineural invasion through regulation of EMMPRIN expression in human salivary adenoid cystic carcinoma. Tumour Biol. 2015; 37(2):2161-9. DOI: 10.1007/s13277-015-4043-5. View

17.

George O, Ness S . Situational awareness: regulation of the myb transcription factor in differentiation, the cell cycle and oncogenesis. Cancers (Basel). 2014; 6(4):2049-71. PMC: 4276956. DOI: 10.3390/cancers6042049. View

18.

Wang Y, Hu J, Wang Y, Ye W, Zhang X, Ju H . EGFR activation induced Snail-dependent EMT and myc-dependent PD-L1 in human salivary adenoid cystic carcinoma cells. Cell Cycle. 2018; 17(12):1457-1470. PMC: 6132955. DOI: 10.1080/15384101.2018.1489177. View

19.

Liang J, Wu Y, Chen B, Zhang W, Tanaka Y, Sugiyama H . The C-kit receptor-mediated signal transduction and tumor-related diseases. Int J Biol Sci. 2013; 9(5):435-43. PMC: 3654492. DOI: 10.7150/ijbs.6087. View

20.

DArdenne A, Kirkpatrick P, Wells C, Davies J . Laminin and fibronectin in adenoid cystic carcinoma. J Clin Pathol. 1986; 39(2):138-44. PMC: 499667. DOI: 10.1136/jcp.39.2.138. View