Evaluation of the Bioaccessibility of a Carotenoid Beadlet Blend Using an in Vitro System Mimicking the Upper Gastrointestinal Tract

Overview

Journal Food Sci Nutr

Specialty Biotechnology

Date 2021 Jun 17

PMID 34136193

Citations 1

Authors

Chun Hu

Dawna Salter Venzon

Katja Lange

Annet Maathuis

Susann Bellmann

Kevin Gellenbeck

Affiliations

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Abstract

The release characteristics of a unique blend of carotenoid beadlets designed to increase bioavailability were tested using the dynamic gastrointestinal model TIM-1. Individual carotenoid bioaccessibility peaks were observed over approximately 3-4 hr in the order of lutein and zeaxanthin first, followed by lycopene, and then finally α- and β-carotene; when tested as a beadlet blend or when the beadlets were compressed into tablets. Bioaccessibility measurements of 7%-20% were similar to those previously reported in literature and comparable between the two formulations, beadlet blend and tablet formulations. Total recovery of carotenoids from all compartments ranged from 70% to 90% for all carotenoids, except lycopene where almost 50% was unrecoverable after digestion in the TIM system.

Citing Articles

Evaluation of the bioaccessibility of a carotenoid beadlet blend using an in vitro system mimicking the upper gastrointestinal tract.

Hu C, Salter Venzon D, Lange K, Maathuis A, Bellmann S, Gellenbeck K Food Sci Nutr. 2021; 9(6):3289-3296.

PMID: 34136193 PMC: 8194940. DOI: 10.1002/fsn3.2295.

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