The Role of Iron Homeostasis and Iron-mediated ROS in Cancer

Overview

Journal Am J Cancer Res

Specialty Oncology

Date 2021 Jun 7

PMID 34094660

Citations 34

Authors

Jia-Fu Ying

Ze-Bei Lu

Luo-Qin Fu

Yu Tong

Zhen Wang

Wei-Fen Li

Xiao-Zhou Mou

Affiliations

Soon will be listed here.

Abstract

As an important trace element, iron plays an essential role in many biology processes like cell proliferation, metabolism, and mitochondrial function. However, the disruption of iron homeostasis tends to cells death and human diseases due to it servers as mediator to promote the production of reactive oxygen species (ROS). In this review, first we introduced the mechanism of complex iron-mediated ROS involved in apoptosis, necroptosis, ferroptosis and pyroptosis. Next, we discussed the controversial role of excess iron and iron deficiency in tumor. Finally, we discussed the anti-cancer effects of iron on both sides, and novel iron-related strategies. This review outlined the mechanisms and regulation of iron homeostasis and iron-mediated ROS in tumors, and discussed the iron-related treatments.

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