Assessment of the Impact of Trace Essential Metals on Cancer Development

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Jul 13

PMID 38999951

Authors

Aleksandra Gorska

Agnieszka Markiewicz-Gospodarek

Mateusz Trubalski

Marta Zerebiec

Julia Poleszak

Renata Markiewicz

Affiliations

Soon will be listed here.

Abstract

This study examines the impact of zinc, copper, cobalt, iron, and manganese on cancer development, considering their dual roles as potential promoters or inhibitors within tumorigenesis. A comprehensive analysis of existing literature and experimental data is conducted to elucidate the intricate relationship between these trace elements and cancer progression. The findings highlight the multifaceted effects of zinc, copper, cobalt, iron, and manganese on various aspects of cancer development, including cell proliferation, angiogenesis, and metastasis. Understanding the nuanced interactions between these trace elements and cancer could offer crucial insights into tumorigenesis mechanisms and facilitate the identification of novel biomarkers and therapeutic targets for cancer prevention and treatment strategies. This research underscores the importance of considering the roles of essential trace elements in cancer biology and may ultimately contribute to advancements in precision medicine approaches for combating cancer.

References

Lener M, Reszka E, Marciniak W, Lesicka M, Baszuk P, Jablonska E . Blood cadmium levels as a marker for early lung cancer detection. J Trace Elem Med Biol. 2020; 64:126682. DOI: 10.1016/j.jtemb.2020.126682. View

Wang X, Zhou M, Liu Y, Si Z . Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies. Cancer Lett. 2023; 561:216157. DOI: 10.1016/j.canlet.2023.216157. View

Tsvetkov P, Coy S, Petrova B, Dreishpoon M, Verma A, Abdusamad M . Copper induces cell death by targeting lipoylated TCA cycle proteins. Science. 2022; 375(6586):1254-1261. PMC: 9273333. DOI: 10.1126/science.abf0529. View

Jomova K, Valko M . Advances in metal-induced oxidative stress and human disease. Toxicology. 2011; 283(2-3):65-87. DOI: 10.1016/j.tox.2011.03.001. View

Shanbhag V, Gudekar N, Jasmer K, Papageorgiou C, Singh K, Petris M . Copper metabolism as a unique vulnerability in cancer. Biochim Biophys Acta Mol Cell Res. 2020; 1868(2):118893. PMC: 7779655. DOI: 10.1016/j.bbamcr.2020.118893. View

Kuang Y, Guo W, Ling J, Xu D, Liao Y, Zhao H . Iron-dependent CDK1 activity promotes lung carcinogenesis via activation of the GP130/STAT3 signaling pathway. Cell Death Dis. 2019; 10(4):297. PMC: 6443808. DOI: 10.1038/s41419-019-1528-y. View

Muto Y, Moroishi T, Ichihara K, Nishiyama M, Shimizu H, Eguchi H . Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis. J Exp Med. 2019; 216(4):950-965. PMC: 6446870. DOI: 10.1084/jem.20180900. View

Ozdemir A, Simay Demir Y, Yesilyurt Z, Ark M . Senescent cells and SASP in cancer microenvironment: New approaches in cancer therapy. Adv Protein Chem Struct Biol. 2023; 133:115-158. DOI: 10.1016/bs.apcsb.2022.10.002. View

Sanchez-Alarcon J, Milic M, Bustamante-Montes L, Isaac-Olive K, Valencia-Quintana R, Ramirez-Duran N . Genotoxicity of Mercury and Its Derivatives Demonstrated In Vitro and In Vivo in Human Populations Studies. Systematic Review. Toxics. 2021; 9(12). PMC: 8704886. DOI: 10.3390/toxics9120326. View

10.

Savi M, Bocchi L, Cacciani F, Vilella R, Buschini A, Perotti A . Cobalt oxide nanoparticles induce oxidative stress and alter electromechanical function in rat ventricular myocytes. Part Fibre Toxicol. 2021; 18(1):1. PMC: 7788732. DOI: 10.1186/s12989-020-00396-6. View

11.

Jelic M, Mandic A, Maricic S, Srdjenovic B . Oxidative stress and its role in cancer. J Cancer Res Ther. 2021; 17(1):22-28. DOI: 10.4103/jcrt.JCRT_862_16. View

12.

Pandrangi S, Chittineedi P, Chikati R, Lingareddy J, Nagoor M, Ponnada S . Role of dietary iron revisited: in metabolism, ferroptosis and pathophysiology of cancer. Am J Cancer Res. 2022; 12(3):974-985. PMC: 8984875. View

13.

Weydert C, Waugh T, Ritchie J, Iyer K, Smith J, Li L . Overexpression of manganese or copper-zinc superoxide dismutase inhibits breast cancer growth. Free Radic Biol Med. 2006; 41(2):226-37. DOI: 10.1016/j.freeradbiomed.2006.03.015. View

14.

Vincent J . New Evidence against Chromium as an Essential Trace Element. J Nutr. 2017; 147(12):2212-2219. DOI: 10.3945/jn.117.255901. View

15.

Fouani L, Menezes S, Paulson M, Richardson D, Kovacevic Z . Metals and metastasis: Exploiting the role of metals in cancer metastasis to develop novel anti-metastatic agents. Pharmacol Res. 2016; 115:275-287. DOI: 10.1016/j.phrs.2016.12.001. View

16.

Czarnek K, Terpilowska S, Siwicki A . Selected aspects of the action of cobalt ions in the human body. Cent Eur J Immunol. 2015; 40(2):236-42. PMC: 4637398. DOI: 10.5114/ceji.2015.52837. View

17.

Korbecki J, Olbromski M, Dziegiel P . CCL18 in the Progression of Cancer. Int J Mol Sci. 2020; 21(21). PMC: 7663205. DOI: 10.3390/ijms21217955. View

18.

Eybl V, Kotyzova D . Protective effect of manganese in cadmium-induced hepatic oxidative damage, changes in cadmium distribution and trace elements level in mice. Interdiscip Toxicol. 2011; 3(2):68-72. PMC: 2984133. DOI: 10.2478/v10102-010-0013-3. View

19.

Marques H . The inorganic chemistry of the cobalt corrinoids - an update. J Inorg Biochem. 2023; 242:112154. DOI: 10.1016/j.jinorgbio.2023.112154. View

20.

Cwiertnia A, Kozlowski M, Cymbaluk-Ploska A . The Role of Iron and Cobalt in Gynecological Diseases. Cells. 2023; 12(1). PMC: 9818544. DOI: 10.3390/cells12010117. View