Increased Hepcidin Expression in Colorectal Carcinogenesis

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2008 Mar 7

PMID 18322945

Citations 39

Authors

Douglas G Ward

Keith Roberts

Matthew J Brookes

Howard Joy

Ashley Martin

Tariq Ismail

Robert Spychal

Tariq Iqbal

Chris Tselepis

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate whether the iron stores regulator hepcidin is implicated in colon cancer-associated anaemia and whether it might have a role in colorectal carcinogenesis.

Methods: Mass spectrometry (MALDI-TOF MS and SELDI-TOF MS) was employed to measure hepcidin in urine collected from 56 patients with colorectal cancer. Quantitative Real Time RT-PCR was utilised to determine hepcidin mRNA expression in colorectal cancer tissue. Hepcidin cellular localisation was determined using immunohistochemistry.

Results: We demonstrate that whilst urinary hepcidin expression was not correlated with anaemia it was positively associated with increasing T-stage of colorectal cancer (P<0.05). Furthermore, we report that hepcidin mRNA is expressed in 34% of colorectal cancer tissue specimens and was correlated with ferroportin repression. This was supported by hepcidin immunoreactivity in colorectal cancer tissue.

Conclusion: We demonstrate that systemic hepcidin expression is unlikely to be the cause of the systemic anaemia associated with colorectal cancer. However, we demonstrate for the first time that hepcidin is expressed by colorectal cancer tissue and that this may represent a novel oncogenic signalling mechanism.

Citing Articles

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Formica V, Riondino S, Morelli C, Guerriero S, DAmore F, Di Grazia A Br J Cancer. 2023; 129(2):222-236.

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Huang L, Li W, Lu Y, Ju Q, Ouyang M Front Oncol. 2023; 13:1098501.

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