Biomarkers in Different Asthma Phenotypes

Overview

Journal Genes (Basel)

Publisher MDPI

Date 2021 Jun 2

PMID 34070316

Citations 18

Authors

Sanja Popovic-Grle

Anamarija Stajduhar

Marina Lampalo

Dina Rnjak

Affiliations

Soon will be listed here.

Abstract

Asthma is the most common respiratory disease. It has multiple phenotypes thatcan be partially differentiated by measuring the disease's specific characteristics-biomarkers. The pathogenetic mechanisms are complex, and it is still a challenge to choose suitable biomarkers to adequately stratify patients, which became especially important with the introduction of biologicals in asthma treatment. Usage of biomarkers and an understanding of the underlying pathobiological mechanisms lead to the definition of endotypes. Asthma can be broadly divided into two endotypes, T2-high and T2-low. The right combination of various biomarkers in different phenotypes is under investigation, hoping to help researchers and clinicians in better disease evaluation since theindividual approach and personalized medicine are imperative. Multiple biomarkers are superior to a single biomarker.

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