Genetic Biomarker Prediction Based on Gender Disparity in Asthma Throughout Machine Learning

Background: Asthma is a chronic respiratory condition affecting populations worldwide, with prevalence ranging from 1-18% across different nations. Gender differences in asthma prevalence have attracted much attention.

Purpose: The aim of this study was to investigate biomarkers of gender differences in asthma prevalence based on machine learning.

Method: The data came from the gene expression omnibus database (GSE69683, GSE76262, and GSE41863), which involved in a number of 575 individuals, including 240 males and 335 females. Theses samples were divided into male group and female group, respectively. Grid search and cross-validation were employed to adjust model parameters for support vector machine, random forest, decision tree and logistic regression model. Accuracy, precision, recall, and F score were used to evaluate the performance of the models during the training process. After model optimization, four machine learning models were utilized to predict biomarkers of sex differences in asthma. In order to validate the accuracy of our results, we performed Wilcoxon tests on the genes expression.

Result: In datasets GSE76262 and GSE69683, support vector machine, random forest, logistic regression, and decision tree all achieve 100% accuracy, precision, recall, and F score. Our findings reveal that XIST serves as a common biomarker among the three samples, comprising a total of 575 individuals, with higher expression levels in females compared to males ( < 0.01).

Conclusion: XIST serves as a genetic biomarker for gender differences in the prevalence of asthma.