Cellulose Acetate-Based Electrospun Materials with a Variety of Biological Potentials: Antibacterial, Antifungal and Anticancer

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2021 Jun 2

PMID 34069809

Citations 5

Authors

Mariya Spasova

Nevena Manolova

Iliya Rashkov

Petya Tsekova

Ani Georgieva

Reneta Toshkova

Nadya Markova

Affiliations

Soon will be listed here.

Abstract

Novel eco-friendly fibrous materials with complex activities from cellulose acetate and cellulose acetate/polyethylene glycol (CA,PEG) containing 5-chloro-8-hydroxyquinoline as a model drug were obtained by electrospinning. Several methods, including scanning electron microscopy, X-ray diffraction analysis, ultraviolet-visible spectroscopy, water contact angle measurements, and mechanical tests, were utilized to characterize the obtained materials. The incorporation of PEG into the fibers facilitated the drug release. The amounts of the released drug from CA/5-Cl8Q and CA,PEG/5-Cl8Q were 78 ± 3.38% and 86 ± 3.02%, respectively (for 175 min). The antibacterial and antifungal activities of the obtained materials were studied. The measured zones of inhibition of CA/5-Cl8Q and CA,PEG/5-Cl8Q mats were 4.0 ± 0.18 and 4.5 ± 0.2 cm against and around 4.0 ± 0.15 and 4.1 ± 0.22 cm against , respectively. The complete inhibition of the growth was detected. The cytotoxicity of the obtained mats was tested toward HeLa cancer cells, SH-4 melanoma skin cells, and mouse BALB/c 3T3 fibroblasts as well. The CA/5-Cl8Q and CA,PEG/5-Cl8Q materials exhibited anticancer activity and low normal cell toxicity. Thus, the obtained fibrous materials can be suitable candidates for wound dressing applications and for application in local cancer treatment.

Citing Articles

5-Amino-8-hydroxyquinoline-containing Electrospun Materials Based on Poly(vinyl alcohol) and Carboxymethyl Cellulose and Their Cu and Fe Complexes with Diverse Biological Properties: Antibacterial, Antifungal and Anticancer.

Ignatova M, Manolova N, Rashkov I, Georgieva A, Toshkova R, Markova N Polymers (Basel). 2023; 15(14).

PMID: 37514529 PMC: 10383330. DOI: 10.3390/polym15143140.

Innovative Fibrous Materials Loaded with 5-Nitro-8-hydroxyquinoline via Electrospinning/Electrospraying Demonstrate Antioxidant, Antimicrobial and Anticancer Activities.

Spasova M, Stoyanova N, Nachev N, Ignatova M, Manolova N, Rashkov I Antioxidants (Basel). 2023; 12(6).

PMID: 37371973 PMC: 10295047. DOI: 10.3390/antiox12061243.

Preparation and Phytotoxicity Evaluation of Cellulose Acetate Nanoparticles.

Lima R, Maranni M, Araujo L, Maciel B, Canassa T, Caires A Polymers (Basel). 2022; 14(22).

PMID: 36433149 PMC: 9695549. DOI: 10.3390/polym14225022.

Bio-Based Electrospun Fibers from Chitosan Schiff Base and Polylactide and Their Cu and Fe Complexes: Preparation and Antibacterial and Anticancer Activities.

Ignatova M, Anastasova I, Manolova N, Rashkov I, Markova N, Kukeva R Polymers (Basel). 2022; 14(22).

PMID: 36433129 PMC: 9696307. DOI: 10.3390/polym14225002.

8-Hydroxyquinoline-5-Sulfonic Acid-Containing Poly(Vinyl Alcohol)/Chitosan Electrospun Materials and Their Cu and Fe Complexes: Preparation, Antibacterial, Antifungal and Antitumor Activities.

Ignatova M, Manolova N, Rashkov I, Markova N, Kukeva R, Stoyanova R Polymers (Basel). 2021; 13(16).

PMID: 34451230 PMC: 8400372. DOI: 10.3390/polym13162690.

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