In Vitro Activities of Cloxyquin (5-chloroquinolin-8-ol) Against Mycobacterium Tuberculosis

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2006 Dec 21

PMID 17178795

Citations 21

Authors

Poonpilas Hongmanee

Kamolchanok Rukseree

Benjamas Buabut

Boontiwa Somsri

Prasit Palittapongarnpim

Affiliations

Soon will be listed here.

Abstract

The in vitro activities of cloxyquin (5-chloroquinolin-8-ol) against 9 standard strains and 150 clinical isolates of Mycobacterium tuberculosis were studied. The MICs ranged from 0.062 to 0.25 microg/ml. The MIC(50) and MIC(90) were 0.125 and 0.25 microg/ml, respectively. These indicate that cloxyquin exhibited good antituberculosis activity, even for multidrug-resistant isolates.

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