Bio-Based Electrospun Fibers from Chitosan Schiff Base and Polylactide and Their Cu and Fe Complexes: Preparation and Antibacterial and Anticancer Activities

Overview

Journal Polymers (Basel)

Publisher MDPI

Date 2022 Nov 26

PMID 36433129

Authors

Milena Ignatova

Ina Anastasova

Nevena Manolova

Iliya Rashkov

Nadya Markova

Rositsa Kukeva

Radostina Stoyanova

Ani Georgieva

Reneta Toshkova

Affiliations

Soon will be listed here.

Abstract

The Schiff base derivative (Ch-8Q) of chitosan (Ch) and 8-hydroxyquinoline-2-carboxaldehyde (8QCHO) was prepared and fibrous mats were obtained by the electrospinning of Ch-8Q/polylactide (PLA) blend solutions in trifluoroacetic acid (TFA). Complexes of the mats were prepared by immersing them in a solution of CuCl or FeCl. Electron paramagnetic resonance (EPR) analysis was performed to examine the complexation of Cu(Fe) in the Ch-8Q/PLA mats complexes. The morphology of the novel materials and their surface chemical composition were studied by scanning electron microscopy (SEM), attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The performed microbiological screening demonstrated that in contrast to the neat PLA mats, the Ch-8Q-containing mats and their complexes were able to kill all bacteria within 3 h of contact. These fibrous materials had efficiency in suppressing the adhesion of pathogenic bacteria . In addition, Ch-8Q/PLA mats and their complexes exerted good anticancer efficacy in vitro against human cervical HeLa cells and human breast MCF-7 cells. The Ch-8Q-containing fibrous materials had no cytotoxicity against non-cancer BALB/c 3T3 mouse fibroblast cells. These properties render the prepared materials promising as wound dressings as well as for application in local cancer treatment.

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