The Molecular Basis of Hypertrophic Scars

Overview

Journal Burns Trauma

Publisher Oxford University Press

Date 2016 Aug 31

PMID 27574672

Citations 48

Authors

Zhensen Zhu

Jie Ding

Edward E Tredget

Affiliations

Soon will be listed here.

Abstract

Hypertrophic scars (HTS) are caused by dermal injuries such as trauma and burns to the deep dermis, which are red, raised, itchy and painful. They can cause cosmetic disfigurement or contractures if craniofacial areas or mobile region of the skin are affected. Abnormal wound healing with more extracellular matrix deposition than degradation will result in HTS formation. This review will introduce the physiology of wound healing, dermal HTS formation, treatment and difference with keloids in the skin, and it also review the current advance of molecular basis of HTS including the involvement of cytokines, growth factors, and macrophages via chemokine pathway, to bring insights for future prevention and treatment of HTS.

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