Importance of Circadian Timing for Aging and Longevity

Overview

Journal Nat Commun

Specialty Biology

Date 2021 May 18

PMID 34001884

Citations 85

Authors

Victoria A Acosta-Rodriguez

Filipa Rijo-Ferreira

Carla B Green

Joseph S Takahashi

Affiliations

Soon will be listed here.

Abstract

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well as by adjusting nutritional composition. Because these factors are often combined during DR, it is unclear which are necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of which change expression throughout the day, suggesting that the timing of drug administration is critical. Here, we discuss how dietary and pharmacological interventions promote a healthy lifespan by influencing energy intake and circadian rhythms.

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