A Review of CXCL1 in Cardiac Fibrosis

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2021 May 17

PMID 33996954

Citations 21

Authors

Cheng-Long Wu

Ran Yin

Su-Nan Wang

Ru Ying

Affiliations

Soon will be listed here.

Abstract

Chemokine C-X-C motif ligand-1 (CXCL1), principally expressed in neutrophils, macrophages and epithelial cells, is a valid pro-inflammatory factor which performs an important role in mediating the infiltration of neutrophils and monocytes/macrophages. Elevated serum level of CXCL1 is considered a pro-inflammatory reaction by the organism. CXCL1 is also related to diverse organs fibrosis according to relevant studies. A growing body of evidence suggests that CXCL1 promotes the process of cardiac remodeling and fibrosis. Here, we review structure and physiological functions of CXCL1 and recent progress on the effects and mechanisms of CXCL1 in cardiac fibrosis. In addition, we explore the role of CXCL1 in the fibrosis of other organs. Besides, we probe the possibility that CXCL1 can be a therapeutic target for the treatment of cardiac fibrosis in cardiovascular diseases.

Citing Articles

Bioinformatics analysis of the expression of potential common genes and immune-related genes between atrial fibrillation and chronic kidney disease.

Teng J, Deng G Front Cardiovasc Med. 2025; 12:1521722.

PMID: 40078458 PMC: 11897265. DOI: 10.3389/fcvm.2025.1521722.

Inflammatory biomarkers and therapeutic potential of milk exosome-mediated CCL7 siRNA in murine intestinal ischemia-reperfusion injury.

Chen W, Xu W, Ma L, Bi C, Yang M, Yang W Front Immunol. 2025; 15:1513196.

PMID: 39902039 PMC: 11788141. DOI: 10.3389/fimmu.2024.1513196.

Exploring the Interplay Between Senescent Osteocytes and Bone Remodeling in Young Rodents.

Song I, Kim P, Choi Y, Chung Y, Lee S, Baek J J Aging Res. 2024; 2024:4213141.

PMID: 39583064 PMC: 11585373. DOI: 10.1155/2024/4213141.

Chemokine receptor CXCR7 antagonism ameliorates cardiac and renal fibrosis induced by mineralocorticoid excess.

Wang B, Robert R, Marques F, Rajapakse N, Kiriazis H, Mackay C Sci Rep. 2024; 14(1):26985.

PMID: 39505939 PMC: 11541864. DOI: 10.1038/s41598-024-75789-0.

Osteogenic mechanism of deciduous teeth periodontal ligament stem cells in inflammatory environment.

Li J, Dai S, Li Z, Guo Q, Liu F Braz J Med Biol Res. 2024; 57:e13606.

PMID: 39383381 PMC: 11463910. DOI: 10.1590/1414-431X2024e13606.

References

Lee S, Cho J, Cho S, Bae C, Kim G, Park D . Establishment of a chronic obstructive pulmonary disease mouse model based on the elapsed time after LPS intranasal instillation. Lab Anim Res. 2018; 34(1):1-10. PMC: 5876158. DOI: 10.5625/lar.2018.34.1.1. View

Shi W, Ju D, Li H, Yuan L, Cui J, Luo D . CD147 Promotes CXCL1 Expression and Modulates Liver Fibrogenesis. Int J Mol Sci. 2018; 19(4). PMC: 5979418. DOI: 10.3390/ijms19041145. View

Zhang Y, Li Y, Shi C, Fu X, Zhao L, Song Y . Angiotensin-(1-7)-mediated Mas1 receptor/NF-κB-p65 signaling is involved in a cigarette smoke-induced chronic obstructive pulmonary disease mouse model. Environ Toxicol. 2017; 33(1):5-15. DOI: 10.1002/tox.22454. View

Stribos E, Seelen M, Goor H, Olinga P, Mutsaers H . Murine Precision-Cut Kidney Slices as an Model to Evaluate the Role of Transforming Growth Factor-β1 Signaling in the Onset of Renal Fibrosis. Front Physiol. 2018; 8:1026. PMC: 5732966. DOI: 10.3389/fphys.2017.01026. View

Russo R, Guabiraba R, Garcia C, Barcelos L, Roffe E, Souza A . Role of the chemokine receptor CXCR2 in bleomycin-induced pulmonary inflammation and fibrosis. Am J Respir Cell Mol Biol. 2008; 40(4):410-21. DOI: 10.1165/rcmb.2007-0364OC. View

Perrault D, Lee G, Bouz A, Sung C, Yu R, Pourmoussa A . Ischemia and reperfusion injury in superficial inferior epigastric artery-based vascularized lymph node flaps. PLoS One. 2020; 15(1):e0227599. PMC: 6954070. DOI: 10.1371/journal.pone.0227599. View

Besnard A, Struyf S, Guabiraba R, Fauconnier L, Rouxel N, Proost P . CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. J Leukoc Biol. 2013; 94(6):1317-23. DOI: 10.1189/jlb.0313140. View

Ravichandran K, Wang Q, Ozkok A, Jani A, Li H, He Z . CD4 T cell knockout does not protect against kidney injury and worsens cancer. J Mol Med (Berl). 2015; 94(4):443-55. DOI: 10.1007/s00109-015-1366-z. View

Berkhout L, Barikbin R, Schiller B, Ravichandran G, Krech T, Neumann K . Deletion of tumour necrosis factor α receptor 1 elicits an increased TH17 immune response in the chronically inflamed liver. Sci Rep. 2019; 9(1):4232. PMC: 6414655. DOI: 10.1038/s41598-019-40324-z. View

10.

Bartling T, Drumm M . Oxidative stress causes IL8 promoter hyperacetylation in cystic fibrosis airway cell models. Am J Respir Cell Mol Biol. 2008; 40(1):58-65. PMC: 2606947. DOI: 10.1165/rcmb.2007-0464OC. View

11.

Cabrera S, Maciel M, Herrera I, Nava T, Vergara F, Gaxiola M . Essential role for the ATG4B protease and autophagy in bleomycin-induced pulmonary fibrosis. Autophagy. 2015; 11(4):670-84. PMC: 4502665. DOI: 10.1080/15548627.2015.1034409. View

12.

Wan R, Mo Y, Zhang Z, Jiang M, Tang S, Zhang Q . Cobalt nanoparticles induce lung injury, DNA damage and mutations in mice. Part Fibre Toxicol. 2017; 14(1):38. PMC: 5604172. DOI: 10.1186/s12989-017-0219-z. View

13.

Amrouche L, Desbuissons G, Rabant M, Sauvaget V, Nguyen C, Benon A . MicroRNA-146a in Human and Experimental Ischemic AKI: CXCL8-Dependent Mechanism of Action. J Am Soc Nephrol. 2016; 28(2):479-493. PMC: 5280013. DOI: 10.1681/ASN.2016010045. View

14.

Liu C, Shi G . Calcium-activated chloride channel regulator 1 (CLCA1): More than a regulator of chloride transport and mucus production. World Allergy Organ J. 2019; 12(11):100077. PMC: 6909348. DOI: 10.1016/j.waojou.2019.100077. View

15.

Braunersreuther V, Montecucco F, Pelli G, Galan K, Proudfoot A, Belin A . Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice. Thromb Haemost. 2013; 110(4):807-25. DOI: 10.1160/TH13-04-0297. View

16.

Tsai Y, Hao S, Chen C, Lin B, Wu W . Involvement of B2 receptor in bradykinin-induced proliferation and proinflammatory effects in human nasal mucosa-derived fibroblasts isolated from chronic rhinosinusitis patients. PLoS One. 2015; 10(5):e0126853. PMC: 4430235. DOI: 10.1371/journal.pone.0126853. View

17.

Peres Leal M, Brochetti R, Ignacio A, Camara N, da Palma R, de Oliveira L . Effects of formaldehyde exposure on the development of pulmonary fibrosis induced by bleomycin in mice. Toxicol Rep. 2018; 5:512-520. PMC: 5977414. DOI: 10.1016/j.toxrep.2018.03.016. View

18.

Ma H, Yamamoto G, Xu J, Liu X, Karin D, Kim J . IL-17 signaling in steatotic hepatocytes and macrophages promotes hepatocellular carcinoma in alcohol-related liver disease. J Hepatol. 2020; 72(5):946-959. PMC: 7167339. DOI: 10.1016/j.jhep.2019.12.016. View

19.

Nishida A, Inatomi O, Fujimoto T, Imaeda H, Tani M, Andoh A . Interleukin-36α Induces Inflammatory Mediators From Human Pancreatic Myofibroblasts Via a MyD88 Dependent Pathway. Pancreas. 2017; 46(4):539-548. DOI: 10.1097/MPA.0000000000000765. View

20.

Guan C, Xiao Y, Li K, Wang T, Liang Y, Liao G . MMP-12 regulates proliferation of mouse macrophages via the ERK/P38 MAPK pathways during inflammation. Exp Cell Res. 2019; 378(2):182-190. DOI: 10.1016/j.yexcr.2019.03.018. View