Green Chemistry Meets Asymmetric Organocatalysis: A Critical Overview on Catalysts Synthesis

Overview

Journal ChemSusChem

Specialty Chemistry

Date 2021 May 13

PMID 33984187

Citations 10

Authors

Achille Antenucci

Stefano Dughera

Polyssena Renzi

Affiliations

Soon will be listed here.

Abstract

Can green chemistry be the right reading key to let organocatalyst design take a step forward towards sustainable catalysis? What if the intriguing chemistry promoted by more engineered organocatalysts was carried on by using renewable and naturally occurring molecular scaffolds, or at least synthetic catalysts more respectful towards the principles of green chemistry? Within the frame of these questions, this Review will tackle the most commonly occurring organic chiral catalysts from the perspective of their synthesis rather than their employment in chemical methodologies or processes. A classification of the catalyst scaffolds based on their E factor will be provided, and the global E factor (E factor) will be proposed as a new green chemistry metric to consider, also, the synthetic route to the catalyst within a given organocatalytic process.

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