New Small γ-turn Type -primary Amino Terminal Tripeptide Organocatalyst for Solvent-free Asymmetric Aldol Reaction of Various Ketones with Aldehydes

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 2

PMID 35493209

Authors

Rajkumar Thiyagarajan

Zubeda Begum

Chigusa Seki

Yuko Okuyama

Eunsang Kwon

Koji Uwai

Michio Tokiwa

Suguru Tokiwa

Mitsuhiro Takeshita

Hiroto Nakano

Affiliations

Soon will be listed here.

Abstract

New small γ-turn type -primary amino terminal tripeptides were synthesized and their functionality as an organocatalyst was examined in the asymmetric aldol reaction of various ketones with different aromatic aldehydes under solvent-free neat conditions to afford the desired chiral -aldol products in good to excellent chemical yields, diastereoselectivities and enantioselectivities (up to 99%, up to : /13 : 87 dr, up to 99% ee).

Citing Articles

New boro amino amide organocatalysts for asymmetric cross aldol reaction of ketones with carbonyl compounds.

Begum Z, Seki C, Okuyama Y, Kwon E, Uwai K, Tokiwa M RSC Adv. 2023; 13(2):888-894.

PMID: 36686933 PMC: 9811241. DOI: 10.1039/d2ra06272k.

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