Interrupting Sitting Time in Postmenopausal Women: Protocol for the Rise for Health Randomized Controlled Trial

Overview

Journal JMIR Res Protoc

Publisher JMIR Publications

Specialty General Medicine

Date 2021 May 13

PMID 33983131

Citations 2

Authors

Sheri J Hartman

Lindsay W Dillon

Andrea Z LaCroix

Loki Natarajan

Dorothy D Sears

Neville Owen

David W Dunstan

James F Sallis

Simon Schenk

Matthew Allison

Michelle Takemoto

Alexandra M Herweck

Bao Nguyen

Dori E Rosenberg

Affiliations

Soon will be listed here.

Abstract

Background: Many older adults spend the majority of their waking hours sitting, which increases their risk of chronic diseases. Given the challenges that many older adults face when engaging in moderate-to-vigorous physical activity, understanding the health benefits of decreasing sitting time and increasing the number of sit-to-stand transitions is needed to address this growing public health concern.

Objective: The aim of this 3-arm randomized controlled trial is to investigate how changes in sitting time and brief sit-to-stand transitions impact biomarkers of healthy aging and physical, emotional, and cognitive functioning compared with a healthy attention control arm.

Methods: Sedentary and postmenopausal women (N=405) will be recruited and randomly assigned to 1 of the 3 study conditions for 3 months: healthy living attention control (Healthy Living), reduce sitting time (Reduce Sitting), and increase sit-to-stand transitions (Increase Transitions). Assessments conducted at baseline and 3 months included fasting blood draw, blood pressure, anthropometric measurements, physical functioning, cognitive testing, and 7 days of a thigh-worn accelerometer (activPAL) and a hip-worn accelerometer (ActiGraph). Blood-based biomarkers of healthy aging included those associated with glycemic control (glycated hemoglobin, fasting plasma insulin and glucose, and homeostatic model assessment of insulin resistance).

Results: Recruitment began in May 2018. The intervention is ongoing, with data collection expected to continue through the end of 2022.

Conclusions: The Rise for Health study is designed to test whether 2 different approaches to interrupting sitting time can improve healthy aging in postmenopausal women. Results from this study may inform the development of sedentary behavior guidelines and interventions to reduce sitting time in older adults.

Trial Registration: ClinicalTrials.gov NCT03473145; https://clinicaltrials.gov/ct2/show/NCT03473145.

International Registered Report Identifier (irrid): DERR1-10.2196/28684.

Citing Articles

Using functional principal component analysis (FPCA) to quantify sitting patterns derived from wearable sensors.

Zablocki R, Hartman S, Di C, Zou J, Carlson J, Hibbing P Int J Behav Nutr Phys Act. 2024; 21(1):48.

PMID: 38671485 PMC: 11055353. DOI: 10.1186/s12966-024-01585-8.

Feasibility of a Health Coach Intervention to Reduce Sitting Time and Improve Physical Functioning Among Breast Cancer Survivors: Pilot Intervention Study.

Tam R, Zablocki R, Liu C, Narayan H, Natarajan L, LaCroix A JMIR Cancer. 2023; 9:e49934.

PMID: 38113082 PMC: 10762618. DOI: 10.2196/49934.

References

Brawley L, Rejeski W, King A . Promoting physical activity for older adults: the challenges for changing behavior. Am J Prev Med. 2003; 25(3 Suppl 2):172-83. DOI: 10.1016/s0749-3797(03)00182-x. View

Wirth K, Klenk J, Brefka S, Dallmeier D, Faehling K, Roque I Figuls M . Biomarkers associated with sedentary behaviour in older adults: A systematic review. Ageing Res Rev. 2016; 35:87-111. DOI: 10.1016/j.arr.2016.12.002. View

Gardner B, Smith L, Aggio D, Iliffe S, Fox K, Jefferis B . 'On Your Feet to Earn Your Seat': update to randomised controlled trial protocol. Trials. 2015; 16:330. PMC: 4525743. DOI: 10.1186/s13063-015-0868-x. View

Guralnik J, Simonsick E, Ferrucci L, Glynn R, Berkman L, Blazer D . A short physical performance battery assessing lower extremity function: association with self-reported disability and prediction of mortality and nursing home admission. J Gerontol. 1994; 49(2):M85-94. DOI: 10.1093/geronj/49.2.m85. View

Chang Y, Bellettiere J, Godbole S, Keshavarz S, Maestas J, Unkart J . Total Sitting Time and Sitting Pattern in Postmenopausal Women Differ by Hispanic Ethnicity and are Associated With Cardiometabolic Risk Biomarkers. J Am Heart Assoc. 2020; 9(4):e013403. PMC: 7070209. DOI: 10.1161/JAHA.119.013403. View

Fitzsimons C, Kirk A, Baker G, Michie F, Kane C, Mutrie N . Using an individualised consultation and activPAL™ feedback to reduce sedentary time in older Scottish adults: results of a feasibility and pilot study. Prev Med. 2013; 57(5):718-20. DOI: 10.1016/j.ypmed.2013.07.017. View

Pilkonis P, Choi S, Reise S, Stover A, Riley W, Cella D . Item banks for measuring emotional distress from the Patient-Reported Outcomes Measurement Information System (PROMIS®): depression, anxiety, and anger. Assessment. 2011; 18(3):263-83. PMC: 3153635. DOI: 10.1177/1073191111411667. View

Owen N, Healy G, Matthews C, Dunstan D . Too much sitting: the population health science of sedentary behavior. Exerc Sport Sci Rev. 2010; 38(3):105-13. PMC: 3404815. DOI: 10.1097/JES.0b013e3181e373a2. View

Harris P, Taylor R, Thielke R, Payne J, Gonzalez N, Conde J . Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support. J Biomed Inform. 2008; 42(2):377-81. PMC: 2700030. DOI: 10.1016/j.jbi.2008.08.010. View

10.

Phillips L, Gardner B . Habitual exercise instigation (vs. execution) predicts healthy adults' exercise frequency. Health Psychol. 2015; 35(1):69-77. DOI: 10.1037/hea0000249. View

11.

Keadle S, Conroy D, Buman M, Dunstan D, Matthews C . Targeting Reductions in Sitting Time to Increase Physical Activity and Improve Health. Med Sci Sports Exerc. 2017; 49(8):1572-1582. PMC: 5511092. DOI: 10.1249/MSS.0000000000001257. View

12.

Sechrist K, Walker S, Pender N . Development and psychometric evaluation of the exercise benefits/barriers scale. Res Nurs Health. 1987; 10(6):357-65. DOI: 10.1002/nur.4770100603. View

13.

Kerr J, Takemoto M, Bolling K, Atkin A, Carlson J, Rosenberg D . Two-Arm Randomized Pilot Intervention Trial to Decrease Sitting Time and Increase Sit-To-Stand Transitions in Working and Non-Working Older Adults. PLoS One. 2016; 11(1):e0145427. PMC: 4703201. DOI: 10.1371/journal.pone.0145427. View

14.

Brierley M, Chater A, Smith L, Bailey D . The Effectiveness of Sedentary Behaviour Reduction Workplace Interventions on Cardiometabolic Risk Markers: A Systematic Review. Sports Med. 2019; 49(11):1739-1767. DOI: 10.1007/s40279-019-01168-9. View

15.

Gao X, Nelson M, Tucker K . Television viewing is associated with prevalence of metabolic syndrome in Hispanic elders. Diabetes Care. 2007; 30(3):694-700. DOI: 10.2337/dc06-1835. View

16.

Grant P, Ryan C, Tigbe W, Granat M . The validation of a novel activity monitor in the measurement of posture and motion during everyday activities. Br J Sports Med. 2006; 40(12):992-7. PMC: 2577473. DOI: 10.1136/bjsm.2006.030262. View

17.

Rice D . Older women's health and access to care. Womens Health Issues. 2000; 10(2):42-6. DOI: 10.1016/s1049-3867(00)00032-3. View

18.

Prince S, Saunders T, Gresty K, Reid R . A comparison of the effectiveness of physical activity and sedentary behaviour interventions in reducing sedentary time in adults: a systematic review and meta-analysis of controlled trials. Obes Rev. 2014; 15(11):905-19. PMC: 4233995. DOI: 10.1111/obr.12215. View

19.

Troiano R, Berrigan D, Dodd K, Masse L, Tilert T, McDowell M . Physical activity in the United States measured by accelerometer. Med Sci Sports Exerc. 2007; 40(1):181-8. DOI: 10.1249/mss.0b013e31815a51b3. View

20.

Melanson Jr E, Freedson P . Validity of the Computer Science and Applications, Inc. (CSA) activity monitor. Med Sci Sports Exerc. 1995; 27(6):934-40. View