In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds

Overview

Journal Mar Drugs

Publisher MDPI

Specialties Biology
Pharmacology

Date 2021 Apr 30

PMID 33921308

Citations 10

Authors

Eun Ju Yun

Sora Yu

Young-Ah Kim

Jing-Jing Liu

Nam Joo Kang

Yong-Su Jin

Kyoung Heon Kim

Affiliations

Soon will be listed here.

Abstract

Numerous health benefits of diets containing red seaweeds or agar-derived sugar mixtures produced by enzymatic or acid hydrolysis of agar have been reported. However, among various agar-derived sugars, the key components that confer health-beneficial effects, such as prebiotic and anti-colon cancer activities, remain unclear. Here, we prepared various agar-derived sugars by multiple enzymatic reactions using an endo-type and an exo-type of β-agarase and a neoagarobiose hydrolase and tested their in vitro prebiotic and anti-colon cancer activities. Among various agar-derived sugars, agarotriose exhibited prebiotic activity that was verified based on the fermentability of agarotriose by probiotic bifidobacteria. Furthermore, we demonstrated the anti-colon cancer activity of 3,6-anhydro-l-galactose, which significantly inhibited the proliferation of human colon cancer cells and induced their apoptosis. Our results provide crucial information regarding the key compounds derived from red seaweeds that confer beneficial health effects, including prebiotic and anti-colon cancer activities, to the host.

Citing Articles

Marine-Derived Polysaccharides and Their Potential Health Benefits in Nutraceutical Applications.

Carrasqueira J, Bernardino S, Bernardino R, Afonso C Mar Drugs. 2025; 23(2).

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The Effects of Agaro-Oligosaccharides Produced by Marine Bacteria ( sp. (HY)) Possessing Agarose-Degrading Enzymes on Myotube Function.

Huang Y, Hirose T, Tsai J, Hirasaka K Mar Drugs. 2024; 22(11).

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Potential therapeutic target for polysaccharide inhibition of colon cancer progression.

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Chemical Composition and Antioxidant Potential of Five Algae Cultivated in Fully Controlled Closed Systems.

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Extracellular production of a thermostable Cellvibrio endolytic β-agarase in Escherichia coli for agarose liquefaction.

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