Anti-colorectal Cancer Effects of Seaweed-derived Bioactive Compounds

Overview

Journal Front Med (Lausanne)

Specialty General Medicine

Date 2022 Sep 5

PMID 36059851

Authors

Yunhua Fu

Dong Xie

Yinghao Zhu

Xinyue Zhang

Hao Yue

Kai Zhu

Zifeng Pi

Yulin Dai

Affiliations

Soon will be listed here.

Abstract

Seaweeds are classified as Chlorophyta, Rhodophyta, and Phaeophyta. They constitute a number of the most significant repositories of new therapeutic compounds for human use. Seaweed has been proven to possess diverse bioactive properties, which include anticancer properties. The present review focuses on colorectal cancer, which is a primary cause of cancer-related mortality in humans. In addition, it discusses various compounds derived from a series of seaweeds that have been shown to eradicate or slow the progression of cancer. Therapeutic compounds extracted from seaweed have shown activity against colorectal cancer. Furthermore, the mechanisms through which these compounds can induce apoptosis and were reviewed. This review emphasizes the potential utility of seaweeds as anticancer agents through the consideration of the capability of compounds present in seaweeds to fight against colorectal cancer.

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References

Fluckiger A, Dumont A, Derangere V, Rebe C, de Rosny C, Causse S . Inhibition of colon cancer growth by docosahexaenoic acid involves autocrine production of TNFα. Oncogene. 2016; 35(35):4611-22. DOI: 10.1038/onc.2015.523. View

Perez M, Falque E, Dominguez H . Antimicrobial Action of Compounds from Marine Seaweed. Mar Drugs. 2016; 14(3). PMC: 4820306. DOI: 10.3390/md14030052. View

Kang M, Kim I, Nam T . Phloroglucinol induces apoptosis via apoptotic signaling pathways in HT-29 colon cancer cells. Oncol Rep. 2014; 32(4):1341-6. PMC: 4148371. DOI: 10.3892/or.2014.3355. View

Ng K, Meyerhardt J, Wu K, Feskanich D, Hollis B, Giovannucci E . Circulating 25-hydroxyvitamin d levels and survival in patients with colorectal cancer. J Clin Oncol. 2008; 26(18):2984-91. DOI: 10.1200/JCO.2007.15.1027. View

Huang G, Liu Z, He L, Luk K, Cheung S, Wong K . Autophagy is an important action mode for functionalized selenium nanoparticles to exhibit anti-colorectal cancer activity. Biomater Sci. 2018; 6(9):2508-2517. DOI: 10.1039/c8bm00670a. View

Newmark H, Yang K, Kurihara N, Fan K, Augenlicht L, Lipkin M . Western-style diet-induced colonic tumors and their modulation by calcium and vitamin D in C57Bl/6 mice: a preclinical model for human sporadic colon cancer. Carcinogenesis. 2008; 30(1):88-92. PMC: 2722141. DOI: 10.1093/carcin/bgn229. View

Wang W, Yang J, Nimiya Y, Lee K, Sanidad K, Qi W . ω-3 Polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. J Nutr Biochem. 2017; 48:29-35. PMC: 6278818. DOI: 10.1016/j.jnutbio.2017.06.006. View

Yi L, Wang Q, Luo H, Lei D, Tang Z, Lei S . Inhibitory Effects of Polyphenols-Rich Components From Three Edible Seaweeds on Inflammation and Colon Cancer . Front Nutr. 2022; 9:856273. PMC: 9136665. DOI: 10.3389/fnut.2022.856273. View

Fasano E, Serini S, Piccioni E, Toesca A, Monego G, Cittadini A . DHA induces apoptosis by altering the expression and cellular location of GRP78 in colon cancer cell lines. Biochim Biophys Acta. 2012; 1822(11):1762-72. DOI: 10.1016/j.bbadis.2012.08.003. View

10.

Palozza P, Torelli C, Boninsegna A, Simone R, Catalano A, Mele M . Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells. Cancer Lett. 2009; 283(1):108-17. DOI: 10.1016/j.canlet.2009.03.031. View

11.

Tarhouni-Jabberi S, Zakraoui O, Ioannou E, Riahi-Chebbi I, Haoues M, Roussis V . Mertensene, a Halogenated Monoterpene, Induces G2/M Cell Cycle Arrest and Caspase Dependent Apoptosis of Human Colon Adenocarcinoma HT29 Cell Line through the Modulation of ERK-1/-2, AKT and NF-κB Signaling. Mar Drugs. 2017; 15(7). PMC: 5532663. DOI: 10.3390/md15070221. View

12.

Martinez Andrade K, Lauritano C, Romano G, Ianora A . Marine Microalgae with Anti-Cancer Properties. Mar Drugs. 2018; 16(5). PMC: 5983296. DOI: 10.3390/md16050165. View

13.

Terasaki M, Ono S, Hashimoto S, Kubota A, Kojima H, Ohta T . Suppression of C-C chemokine receptor 1 is a key regulation for colon cancer chemoprevention in AOM/DSS mice by fucoxanthin. J Nutr Biochem. 2021; 99:108871. DOI: 10.1016/j.jnutbio.2021.108871. View

14.

Rocha D, Seca A, Pinto D . Seaweed Secondary Metabolites In Vitro and In Vivo Anticancer Activity. Mar Drugs. 2018; 16(11). PMC: 6266495. DOI: 10.3390/md16110410. View

15.

Ohmori H, Luo Y, Fujii K, Sasahira T, Shimomoto T, Denda A . Dietary linoleic acid and glucose enhances azoxymethane-induced colon cancer and metastases via the expression of high-mobility group box 1. Pathobiology. 2010; 77(4):210-7. DOI: 10.1159/000296305. View

16.

Al-Aadily I, Bajilan S, Al-Koofee D, Al-Marzoqi A . Anticancer Effect of Sargassum oligocystom Hydroalcoholic Extract Against SW742, HT-29, WiDr, and CT-26 Colorectal Cancer Cell Lines and Expression of P53 and APC Genes. J Gastrointest Cancer. 2022; 54(1):62-66. DOI: 10.1007/s12029-021-00765-0. View

17.

Han Y, Lee J, Lee S . Antitumor Effects of Fucoidan on Human Colon Cancer Cells via Activation of Akt Signaling. Biomol Ther (Seoul). 2015; 23(3):225-32. PMC: 4428714. DOI: 10.4062/biomolther.2014.136. View

18.

Zarate R, El Jaber-Vazdekis N, Tejera N, Perez J, Rodriguez C . Significance of long chain polyunsaturated fatty acids in human health. Clin Transl Med. 2017; 6(1):25. PMC: 5532176. DOI: 10.1186/s40169-017-0153-6. View

19.

Rawson J, Sun Z, Dicks E, Daftary D, Parfrey P, Green R . Vitamin D intake is negatively associated with promoter methylation of the Wnt antagonist gene DKK1 in a large group of colorectal cancer patients. Nutr Cancer. 2012; 64(7):919-28. PMC: 4323165. DOI: 10.1080/01635581.2012.711418. View

20.

Thanh T, Quach T, Nguyen T, Vu Luong D, Bui M, Tran T . Structure and cytotoxic activity of ulvan extracted from green seaweed Ulva lactuca. Int J Biol Macromol. 2016; 93(Pt A):695-702. DOI: 10.1016/j.ijbiomac.2016.09.040. View