The Effect of S. Y. Hu Extract and Its Fractions on Renal Morphology in Rats Fed with Normal and High-Cholesterol Diet

Overview

Journal Foods

Specialty Biotechnology

Date 2021 Apr 30

PMID 33918905

Citations 7

Authors

Piotr Kuropka

Anna Zwyrzykowska-Wodzinska

Robert Kupczynski

Maciej Wlodarczyk

Antoni Szumny

Renata M Nowaczyk

Affiliations

Soon will be listed here.

Abstract

Therapeutic properties of species are widely used in natural medicine. may become a potential substitute for (Yerba Mate). As a part of the preliminary safety verification of this European hybrid vs. Yerba Mate, an eight-week study concerning the impact of regular administration of leaves of both species on kidneys was conducted. The standard water infusion and three dominant fractions of leaves' constituents (polyphenols, saponins and less polar terpenoids) were separately tried on 96 male Wistar rats divided into 8-member groups. Animals were divided into two basic nutritional groups: the first one was rats fed standard feed and the second on was rats fed with high-cholesterol diet (20 g of cholesterol per kg of standard feed). Postmortem morphometric evaluation of stained kidney samples concerned the filtration barrier elements, which are crucial in proper diuresis. The results showed that saponins present in the hydroalcoholic dry extract (administered in a dose of 10 mg/kg of body weight/day) as well as in water infusions (1:20) from and do not demonstrate nephrotoxicity but conversely, have a protective role on kidney status in animals fed with a normal diet and in a high-cholesterol diet.

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References

Cho A, Jeon S, Kim M, Yeo J, Seo K, Choi M . Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol. 2010; 48(3):937-43. DOI: 10.1016/j.fct.2010.01.003. View

Jarad G, Cunningham J, Shaw A, Miner J . Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier. J Clin Invest. 2006; 116(8):2272-9. PMC: 1523402. DOI: 10.1172/JCI28414. View

Scott R, Quaggin S . Review series: The cell biology of renal filtration. J Cell Biol. 2015; 209(2):199-210. PMC: 4411276. DOI: 10.1083/jcb.201410017. View

Arcari D, Bartchewsky W, dos Santos T, Oliveira K, Funck A, Pedrazzoli J . Antiobesity effects of yerba maté extract (Ilex paraguariensis) in high-fat diet-induced obese mice. Obesity (Silver Spring). 2009; 17(12):2127-33. DOI: 10.1038/oby.2009.158. View

Miner J . The glomerular basement membrane. Exp Cell Res. 2012; 318(9):973-8. PMC: 3334451. DOI: 10.1016/j.yexcr.2012.02.031. View

Bracesco N, Sanchez A, CONTRERAS V, Menini T, Gugliucci A . Recent advances on Ilex paraguariensis research: minireview. J Ethnopharmacol. 2010; 136(3):378-84. DOI: 10.1016/j.jep.2010.06.032. View

Wlodarczyk M, Szumny A, Glensk M . Lanostane-Type Saponins from . Molecules. 2019; 24(8). PMC: 6515439. DOI: 10.3390/molecules24081606. View

Kataoka S, Norikura T, Sato S . Maternal green tea polyphenol intake during lactation attenuates kidney injury in high-fat-diet-fed male offspring programmed by maternal protein restriction in rats. J Nutr Biochem. 2018; 56:99-108. DOI: 10.1016/j.jnutbio.2018.01.012. View

Salmon A, Neal C, Harper S . New aspects of glomerular filtration barrier structure and function: five layers (at least) not three. Curr Opin Nephrol Hypertens. 2009; 18(3):197-205. DOI: 10.1097/MNH.0b013e328329f837. View

10.

Murakami A . Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents. Arch Biochem Biophys. 2014; 557:3-10. DOI: 10.1016/j.abb.2014.04.018. View

11.

Dartora N, de Souza L, Paiva S, Scoparo C, Iacomini M, Gorin P . Rhamnogalacturonan from Ilex paraguariensis: a potential adjuvant in sepsis treatment. Carbohydr Polym. 2013; 92(2):1776-82. DOI: 10.1016/j.carbpol.2012.11.013. View

12.

Negrin A, Long C, Motley T, Kennelly E . LC-MS Metabolomics and Chemotaxonomy of Caffeine-Containing Holly ( Ilex) Species and Related Taxa in the Aquifoliaceae. J Agric Food Chem. 2019; 67(19):5687-5699. DOI: 10.1021/acs.jafc.8b07168. View

13.

Hu T, He X, Jiang J, Xu X . Efficacy evaluation of a Chinese bitter tea (Ilex latifolia Thunb.) via analyses of its main components. Food Funct. 2014; 5(5):876-81. DOI: 10.1039/c3fo60603a. View

14.

Balzan S, Hernandes A, Reichert C, Donaduzzi C, Pires V, Gasparotto Jr A . Lipid-lowering effects of standardized extracts of Ilex paraguariensis in high-fat-diet rats. Fitoterapia. 2013; 86:115-22. DOI: 10.1016/j.fitote.2013.02.008. View

15.

De Oliveira E, Lima N, Conceicao E, Peixoto-Silva N, Moura E, Lisboa P . Treatment with Ilex paraguariensis (yerba mate) aqueous solution prevents hepatic redox imbalance, elevated triglycerides, and microsteatosis in overweight adult rats that were precociously weaned. Braz J Med Biol Res. 2018; 51(6):e7342. PMC: 6002129. DOI: 10.1590/1414-431x20187342. View

16.

de Andrade F, de Albuquerque C, Maraschin M, Luiz da Silva E . Safety assessment of yerba mate (Ilex paraguariensis) dried extract: results of acute and 90 days subchronic toxicity studies in rats and rabbits. Food Chem Toxicol. 2011; 50(2):328-34. DOI: 10.1016/j.fct.2011.08.028. View

17.

Jarad G, Miner J . Update on the glomerular filtration barrier. Curr Opin Nephrol Hypertens. 2009; 18(3):226-32. PMC: 2895306. DOI: 10.1097/mnh.0b013e3283296044. View

18.

Gao H, Long Y, Jiang X, Liu Z, Wang D, Zhao Y . Beneficial effects of Yerba Mate tea (Ilex paraguariensis) on hyperlipidemia in high-fat-fed hamsters. Exp Gerontol. 2013; 48(6):572-8. DOI: 10.1016/j.exger.2013.03.008. View

19.

de Resende P, Verza S, Kaiser S, Gomes L, Kucharski L, Ortega G . The activity of mate saponins (Ilex paraguariensis) in intra-abdominal and epididymal fat, and glucose oxidation in male Wistar rats. J Ethnopharmacol. 2012; 144(3):735-40. DOI: 10.1016/j.jep.2012.10.023. View

20.

Gluba-Brzozka A, Franczyk B, Rysz J . Cholesterol Disturbances and the Role of Proper Nutrition in CKD Patients. Nutrients. 2019; 11(11). PMC: 6893650. DOI: 10.3390/nu11112820. View