An R2R3-MYB Transcription Factor Positively Regulates the Glandular Secretory Trichome Initiation in L

Overview

Journal Front Plant Sci

Date 2021 Apr 26

PMID 33897745

Citations 20

Authors

Wei Qin

Lihui Xie

Yongpeng Li

Hang Liu

Xueqing Fu

Tiantian Chen

Danial Hassani

Ling Li

Xiaofen Sun

Kexuan Tang

Affiliations

Soon will be listed here.

Abstract

L. is known for its specific product "artemisinin" which is an active ingredient for curing malaria. Artemisinin is secreted and accumulated in the glandular secretory trichomes (GSTs) on leaves. Earlier studies have shown that increasing GST density is effective in increasing artemisinin content. However, the mechanism of GST initiation is not fully understood. To this end, we isolated and characterized an R2R3-MYB gene, , which is expressed specifically in the GSTs of shoot tips. Overexpression of in increased GST density and enhanced the artemisinin content, whereas RNA interference of resulted in the reduction of GST density and artemisinin content. Additionally, neither overexpression lines nor RNAi lines showed an abnormal phenotype in plant growth and the morphology of GSTs. Our study demonstrates that AaMYB17 is a positive regulator of GSTs' initiation, without influencing the trichome morphology.

Citing Articles

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Yang Y, Li Y, Jin L, Li P, Zhou Q, Sheng M BMC Genomics. 2024; 25(1):776.

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Advanced metabolic engineering strategies for increasing artemisinin yield in L.

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