Human Tissue Distribution of Anidulafungin and Micafungin

Overview

Journal Antimicrob Agents Chemother

Publisher American Society for Microbiology

Specialty Pharmacology

Date 2021 Apr 20

PMID 33875434

Citations 2

Authors

Jana Marx

Rene Welte

Tiziana Gasperetti

Patrizia Moser

Michael Joannidis

Romuald Bellmann

Affiliations

Soon will be listed here.

Abstract

Concentrations of anidulafungin and micafungin were determined in eight different tissues obtained during autopsy of four deceased individuals who had been treated with anidulafungin and of seven who had received micafungin. The largest amounts were recovered from liver, with anidulafungin concentrations of 11.01 to 66.50 μg/g and micafungin levels of 0.36 to 5.53 μg/g (0.65 μg/g 30 days after the last administration). The lowest anidulafungin levels were measured in skeletal muscle, and the lowest micafungin concentrations were in kidneys.

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References

Walsh T, Goutelle S, Jelliffe R, Golden J, Little E, DeVoe C . Intrapulmonary pharmacokinetics and pharmacodynamics of micafungin in adult lung transplant patients. Antimicrob Agents Chemother. 2010; 54(8):3451-9. PMC: 2916355. DOI: 10.1128/AAC.01647-09. View

Collette N, Van der Auwera P, Lopez A, Heymans C, Meunier F . Tissue concentrations and bioactivity of amphotericin B in cancer patients treated with amphotericin B-deoxycholate. Antimicrob Agents Chemother. 1989; 33(3):362-8. PMC: 171494. DOI: 10.1128/AAC.33.3.362. View

Odabasi Z, Paetznick V, Rex J, Ostrosky-Zeichner L . Effects of serum on in vitro susceptibility testing of echinocandins. Antimicrob Agents Chemother. 2007; 51(11):4214-6. PMC: 2151461. DOI: 10.1128/AAC.01589-06. View

Nicasio A, Tessier P, Nicolau D, Knauft R, Russomanno J, Shore E . Bronchopulmonary disposition of micafungin in healthy adult volunteers. Antimicrob Agents Chemother. 2008; 53(3):1218-20. PMC: 2650581. DOI: 10.1128/AAC.01386-08. View

Tissot F, Agrawal S, Pagano L, Petrikkos G, Groll A, Skiada A . ECIL-6 guidelines for the treatment of invasive candidiasis, aspergillosis and mucormycosis in leukemia and hematopoietic stem cell transplant patients. Haematologica. 2016; 102(3):433-444. PMC: 5394968. DOI: 10.3324/haematol.2016.152900. View

Bellmann R, Smuszkiewicz P . Pharmacokinetics of antifungal drugs: practical implications for optimized treatment of patients. Infection. 2017; 45(6):737-779. PMC: 5696449. DOI: 10.1007/s15010-017-1042-z. View

Crandon J, Banevicius M, Fang A, Crownover P, Knauft R, Pope J . Bronchopulmonary disposition of intravenous voriconazole and anidulafungin given in combination to healthy adults. Antimicrob Agents Chemother. 2009; 53(12):5102-7. PMC: 2786330. DOI: 10.1128/AAC.01042-09. View

Damle B, Stogniew M, Dowell J . Pharmacokinetics and tissue distribution of anidulafungin in rats. Antimicrob Agents Chemother. 2008; 52(7):2673-6. PMC: 2443878. DOI: 10.1128/AAC.01596-07. View

Ernst E, Roling E, Petzold C, Keele D, Klepser M . In vitro activity of micafungin (FK-463) against Candida spp.: microdilution, time-kill, and postantifungal-effect studies. Antimicrob Agents Chemother. 2002; 46(12):3846-53. PMC: 132786. DOI: 10.1128/AAC.46.12.3846-3853.2002. View

10.

Vogelsinger H, Weiler S, Djanani A, Kountchev J, Bellmann-Weiler R, Wiedermann C . Amphotericin B tissue distribution in autopsy material after treatment with liposomal amphotericin B and amphotericin B colloidal dispersion. J Antimicrob Chemother. 2006; 57(6):1153-60. DOI: 10.1093/jac/dkl141. View

11.

Niwa T, Yokota Y, Tokunaga A, Yamato Y, Kagayama A, Fujiwara T . Tissue distribution after intravenous dosing of micafungin, an antifungal drug, to rats. Biol Pharm Bull. 2004; 27(7):1154-6. DOI: 10.1248/bpb.27.1154. View

12.

Welte R, Eller P, Lorenz I, Joannidis M, Bellmann R . Anidulafungin Pharmacokinetics in Ascites Fluid and Pleural Effusion of Critically Ill Patients. Antimicrob Agents Chemother. 2018; 62(4). PMC: 5913985. DOI: 10.1128/AAC.02326-17. View

13.

Groll A, Mickiene D, Petraitiene R, Petraitis V, Lyman C, Bacher J . Pharmacokinetic and pharmacodynamic modeling of anidulafungin (LY303366): reappraisal of its efficacy in neutropenic animal models of opportunistic mycoses using optimal plasma sampling. Antimicrob Agents Chemother. 2001; 45(10):2845-55. PMC: 90741. DOI: 10.1128/AAC.45.10.2845-2855.2001. View

14.

Cornely O, Bassetti M, Calandra T, Garbino J, Kullberg B, Lortholary O . ESCMID* guideline for the diagnosis and management of Candida diseases 2012: non-neutropenic adult patients. Clin Microbiol Infect. 2012; 18 Suppl 7:19-37. DOI: 10.1111/1469-0691.12039. View

15.

Christiansen K, Bernard E, Gold J, Armstrong D . Distribution and activity of amphotericin B in humans. J Infect Dis. 1985; 152(5):1037-43. DOI: 10.1093/infdis/152.5.1037. View

16.

Welte R, Oberacher H, Schwarzler B, Joannidis M, Bellmann R . Quantification of anidulafungin and micafungin in human body fluids by high performance-liquid chromatography with UV-detection. J Chromatogr B Analyt Technol Biomed Life Sci. 2020; 1139:121937. DOI: 10.1016/j.jchromb.2019.121937. View

17.

Felton T, Troke P, Hope W . Tissue penetration of antifungal agents. Clin Microbiol Rev. 2014; 27(1):68-88. PMC: 3910906. DOI: 10.1128/CMR.00046-13. View

18.

Pappas P, Kauffman C, Andes D, Clancy C, Marr K, Ostrosky-Zeichner L . Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America. Clin Infect Dis. 2016; 62(4):409-17. DOI: 10.1093/cid/civ1194. View

19.

Gonzalez-Lara M, Ostrosky-Zeichner L . Invasive Candidiasis. Semin Respir Crit Care Med. 2020; 41(1):3-12. DOI: 10.1055/s-0040-1701215. View

20.

Groll A, Mickiene D, Petraitis V, Petraitiene R, Ibrahim K, Piscitelli S . Compartmental pharmacokinetics and tissue distribution of the antifungal echinocandin lipopeptide micafungin (FK463) in rabbits. Antimicrob Agents Chemother. 2001; 45(12):3322-7. PMC: 90832. DOI: 10.1128/AAC.45.12.3322-3327.2001. View