Amphotericin B Tissue Distribution in Autopsy Material After Treatment with Liposomal Amphotericin B and Amphotericin B Colloidal Dispersion

Overview

Journal J Antimicrob Chemother

Publisher Oxford University Press

Specialty Infectious Diseases

Date 2006 Apr 22

PMID 16627591

Citations 48

Authors

Helene Vogelsinger

Stefan Weiler

Angela Djanani

Jordan Kountchev

Rosa Bellmann-Weiler

Christian J Wiedermann

Romuald Bellmann

Affiliations

Soon will be listed here.

Abstract

Objectives: Tissue concentrations of amphotericin B were determined in autopsy material of patients who had been treated with liposomal amphotericin B or amphotericin B colloidal dispersion (colloidal amphotericin B) for suspected or proven invasive fungal infection.

Patients And Methods: Amphotericin B tissue levels were measured in liver, spleen, lung, kidney, and myocardial and brain tissue of 20 patients who had been treated with lipid-formulated amphotericin B, before they died from multi-organ failure. Seven patients had been treated with liposomal amphotericin B (AmBisome) and thirteen with colloidal amphotericin B (Amphocil). Tissue samples were obtained during routine autopsy, homogenized and extracted with methanol. Amphotericin B concentrations were measured using HPLC after purification by solid phase extraction.

Results: The highest amphotericin B levels were found in liver and spleen, followed by kidney, lung, myocardium and brain. In the lung higher amphotericin B concentrations were found after treatment with amphotericin B colloidal dispersion than after therapy with liposomal amphotericin B.

Conclusions: The choice of lipid formulation may influence amphotericin B penetration into the lung.

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