Personalized Genome Structure Via Single Gamete Sequencing

Overview

Journal Genome Biol

Specialties Biology
Genetics

Date 2021 Apr 20

PMID 33874978

Citations 8

Authors

Ruqian Lyu

Vanessa Tsui

Davis J McCarthy

Wayne Crismani

Affiliations

Soon will be listed here.

Abstract

Genetic maps have been fundamental to building our understanding of disease genetics and evolutionary processes. The gametes of an individual contain all of the information required to perform a de novo chromosome-scale assembly of an individual's genome, which historically has been performed with populations and pedigrees. Here, we discuss how single-cell gamete sequencing offers the potential to merge the advantages of short-read sequencing with the ability to build personalized genetic maps and open up an entirely new space in personalized genetics.

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