Antioxidant Effect of Polysaccharides in D-Galactose-Induced Heart Aging Mice

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2021 Apr 16

PMID 33860051

Citations 27

Authors

Wanjun Ma

Shanshan Wei

Weijun Peng

Taoli Sun

Jianhua Huang

Rong Yu

Bikui Zhang

Wenqun Li

Affiliations

Soon will be listed here.

Abstract

polysaccharides (PSP), the extract of , are demonstrated to exhibit a wide range of pharmacological activities. A recent study reported that PSP alleviated the aging of the kidney and meninges. However, the effect of PSP on heart aging remains unclear. The present study is aimed at investigating the protection of PSP on D-galactose- (D-gal-) induced heart aging. Results showed that irregularly arranged cardiac muscle fibers were observed in heart tissues of D-gal-treated mice, and the levels of cardiac troponin T (cTnT), creatine kinase (CK), p21, and p53 were increased after D-gal treatment. D-gal-induced heart aging and injury can be attenuated by oral administration of PSP. Moreover, PSP also decreased reactive oxygen species (ROS) and malondialdehyde (MDA) and increased the level of superoxide dismutase (SOD) in the hearts of D-gal-treated mice. DNA damages and lipid peroxidation induced by oxidative stress were also inhibited by PSP as indicated by reduced levels of 8-hydroxydeoxyguanosine (8-OHdG) and 4-hydroxy-2-nonenal (4-HNE). Collectively, PSP attenuated D-gal-induced heart aging via inhibiting oxidative stress, suggesting that PSP might serve as a potential effective Chinese herbal active constituent for antiaging therapy.

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References

Liu N, Dong Z, Zhu X, Xu H, Zhao Z . Characterization and protective effect of Polygonatum sibiricum polysaccharide against cyclophosphamide-induced immunosuppression in Balb/c mice. Int J Biol Macromol. 2017; 107(Pt A):796-802. DOI: 10.1016/j.ijbiomac.2017.09.051. View

Marin-Garcia J, Pi Y, Goldenthal M . Mitochondrial-nuclear cross-talk in the aging and failing heart. Cardiovasc Drugs Ther. 2006; 20(6):477-91. DOI: 10.1007/s10557-006-0584-6. View

Dong X, Hui Z, Xiang W, Rong Z, Jian S, Zhu C . Ginkgo biloba extract reduces endothelial progenitor-cell senescence through augmentation of telomerase activity. J Cardiovasc Pharmacol. 2007; 49(2):111-5. DOI: 10.1097/FJC.0b013e31802ef519. View

Majdi A, Sadigh-Eteghad S, Talebi M, Farajdokht F, Erfani M, Mahmoudi J . Nicotine Modulates Cognitive Function in -Galactose-Induced Senescence in Mice. Front Aging Neurosci. 2018; 10:194. PMC: 6055060. DOI: 10.3389/fnagi.2018.00194. View

Yang J, Wu S, Huang X, Hu X, Zhang Y . Hypolipidemic Activity and Antiatherosclerotic Effect of Polysaccharide of Polygonatum sibiricum in Rabbit Model and Related Cellular Mechanisms. Evid Based Complement Alternat Med. 2015; 2015:391065. PMC: 4451159. DOI: 10.1155/2015/391065. View

Li W, Tan S, Li X, Sun T, Li D, Du J . Calcitonin gene-related peptide inhibits the cardiac fibroblasts senescence in cardiac fibrosis via up-regulating klotho expression. Eur J Pharmacol. 2018; 843:96-103. DOI: 10.1016/j.ejphar.2018.10.023. View

Zong S, Zeng G, Zou B, Li K, Fang Y, Lu L . Effects of Polygonatum sibiricum polysaccharide on the osteogenic differentiation of bone mesenchymal stem cells in mice. Int J Clin Exp Pathol. 2015; 8(6):6169-80. PMC: 4525828. View

Wang Y, Qin S, Pen G, Chen D, Han C, Miao C . Original Research: Potential ocular protection and dynamic observation of Polygonatum sibiricum polysaccharide against streptozocin-induced diabetic rats' model. Exp Biol Med (Maywood). 2016; 242(1):92-101. PMC: 5206980. DOI: 10.1177/1535370216663866. View

Zhu X, Wu W, Chen X, Yang F, Zhang J, Hou J . Protective effects of Polygonatum sibiricum polysaccharide on acute heart failure in rats 1. Acta Cir Bras. 2018; 33(10):868-878. DOI: 10.1590/s0102-865020180100000001. View

10.

Klimiuk A, Zalewska A, Sawicki R, Knapp M, Maciejczyk M . Salivary Oxidative Stress Increases With the Progression of Chronic Heart Failure. J Clin Med. 2020; 9(3). PMC: 7141370. DOI: 10.3390/jcm9030769. View

11.

Rai P, Onder T, Young J, McFaline J, Pang B, Dedon P . Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence. Proc Natl Acad Sci U S A. 2009; 106(1):169-74. PMC: 2629241. DOI: 10.1073/pnas.0809834106. View

12.

Phu H, Thuan D, Nguyen T, Posadino A, Eid A, Pintus G . Herbal Medicine for Slowing Aging and Aging-associated Conditions: Efficacy, Mechanisms and Safety. Curr Vasc Pharmacol. 2019; 18(4):369-393. DOI: 10.2174/1570161117666190715121939. View

13.

Ashok B, Ali R . The aging paradox: free radical theory of aging. Exp Gerontol. 1999; 34(3):293-303. DOI: 10.1016/s0531-5565(99)00005-4. View

14.

Yaffee D, Williams M . Cardiovascular Surgery in the Elderly. Semin Thorac Cardiovasc Surg. 2017; 28(4):741-747. DOI: 10.1053/j.semtcvs.2016.08.007. View

15.

Schaar C, Dues D, Spielbauer K, Machiela E, Cooper J, Senchuk M . Mitochondrial and cytoplasmic ROS have opposing effects on lifespan. PLoS Genet. 2015; 11(2):e1004972. PMC: 4335496. DOI: 10.1371/journal.pgen.1004972. View

16.

Zimmermann A, Kainz K, Hofer S, Bauer M, Schroeder S, Dengjel J . 4,4'Dimethoxychalcone: a natural flavonoid that promotes health through autophagy-dependent and -independent effects. Autophagy. 2019; 15(9):1662-1664. PMC: 6693465. DOI: 10.1080/15548627.2019.1632623. View

17.

Cebe T, Yanar K, Atukeren P, Ozan T, Kuruc A, Kunbaz A . A comprehensive study of myocardial redox homeostasis in naturally and mimetically aged rats. Age (Dordr). 2014; 36(6):9728. PMC: 4226800. DOI: 10.1007/s11357-014-9728-y. View

18.

Wang L, Cao Q, Wen K, Xiao Y, Chen T, Guan X . CD38 Deficiency Alleviates D-Galactose-Induced Myocardial Cell Senescence Through NAD/Sirt1 Signaling Pathway. Front Physiol. 2019; 10:1125. PMC: 6735286. DOI: 10.3389/fphys.2019.01125. View

19.

Gavin P, Song N, Kim S, Lipchik C, Johnson N, Bandos H . Association of Polymorphisms in FCGR2A and FCGR3A With Degree of Trastuzumab Benefit in the Adjuvant Treatment of ERBB2/HER2-Positive Breast Cancer: Analysis of the NSABP B-31 Trial. JAMA Oncol. 2016; 3(3):335-341. PMC: 5344747. DOI: 10.1001/jamaoncol.2016.4884. View

20.

Davalli P, Mitic T, Caporali A, Lauriola A, DArca D . ROS, Cell Senescence, and Novel Molecular Mechanisms in Aging and Age-Related Diseases. Oxid Med Cell Longev. 2016; 2016:3565127. PMC: 4877482. DOI: 10.1155/2016/3565127. View