The Recent Advance and Prospect of Natural Source Compounds for the Treatment of Heart Failure

Overview

Journal Heliyon

Specialty Social Sciences

Date 2024 Mar 6

PMID 38444481

Authors

Xing-Juan Chen

Si-Yuan Liu

Si-Ming Li

Ji-Kang Feng

Ying Hu

Xiao-Zhen Cheng

Cheng-Zhi Hou

Yun Xu

Mu Hu

Ling Feng

Lu Xiao

Affiliations

Soon will be listed here.

Abstract

Heart failure is a continuously developing syndrome of cardiac insufficiency caused by diseases, which becomes a major disease endangering human health as well as one of the main causes of death in patients with cardiovascular diseases. The occurrence of heart failure is related to hemodynamic abnormalities, neuroendocrine hormones, myocardial damage, myocardial remodeling , lead to the clinical manifestations including dyspnea, fatigue and fluid retention with complex pathophysiological mechanisms. Currently available drugs such as cardiac glycoside, diuretic, angiotensin-converting enzyme inhibitor, vasodilator and β receptor blocker are widely used for the treatment of heart failure. In particular, natural products and related active ingredients have the characteristics of mild efficacy, low toxicity, multi-target comprehensive efficacy, and have obvious advantages in restoring cardiac function, reducing energy disorder and improving quality of life. In this review, we mainly focus on the recent advance including mechanisms and active ingredients of natural products for the treatment of heart failure, which will provide the inspiration for the development of more potent clinical drugs against heart failure.

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