Health-Promoting Activities and Associated Mechanisms of Polygonati Rhizoma Polysaccharides

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2023 Feb 11

PMID 36771015

Authors

Shuzhen Wang

Feng He

Hongmei Wu

Fu Xiang

Hongyan Zheng

Wei Wu

Shiming Li

Affiliations

Soon will be listed here.

Abstract

Polygonati Rhizoma, a typical homology of medicine and food, possesses remarkable anti-fatigue, anti-aging, metabolic regulatory, immunomodulatory, anti-inflammatory, neuroprotective, anti-diabetes, and anti-cancer effects. Among bioactive phytochemicals in Polygonati Rhizoma, polysaccharides play important roles in the health-promoting activities through the mechanisms mentioned above and potential synergistic effects with other bioactives. In this review, we briefly introduce the updated biosynthesis of polysaccharides, the purification method, the structure characterization, and food applications, and discuss in detail the biological activities of Polygonati Rhizoma polysaccharides and associated mechanisms, aiming at broadening the usage of Polygonati Rhizoma as functional food and medicine.

Citing Articles

Metabolomics and network pharmacology-based identification of phenolic acids in Polygonatum kingianum var. grandifolium rhizomes as anti-cancer/Tumor active ingredients.

Wan X, Cui L, Xiao Q PLoS One. 2024; 19(12):e0315857.

PMID: 39689118 PMC: 11651577. DOI: 10.1371/journal.pone.0315857.

Characteristics of the effects of Polygonati Rhizoma on gut microbiota and metabolites in vitro associated with poor dietary habits in pregnant women.

Xu Z, Li J, Hong L, Zhang Y, Wang C, Yang H PLoS One. 2024; 19(12):e0314335.

PMID: 39637062 PMC: 11620700. DOI: 10.1371/journal.pone.0314335.

Lipid-lowering and antioxidant effects of fermented liquor: a study on intestinal microbiota and brain-gut axis in mice.

Yang X, Fang L, Shen J, Tan Z, Zeng W, Peng M Front Nutr. 2024; 11:1428228.

PMID: 39221162 PMC: 11362044. DOI: 10.3389/fnut.2024.1428228.

Antitumor activity of Polygonatum sibiricum polysaccharides.

Lai W, Ning Q, Wang G, Gao Y, Liao S, Tang S Arch Pharm Res. 2024; 47(8-9):696-708.

PMID: 39060656 DOI: 10.1007/s12272-024-01511-3.

Interpreting the Mechanism of Active Ingredients in Polygonati Rhizoma in Treating Depression by Combining Systemic Pharmacology and In Vitro Experiments.

Wei X, Wang D, Liu J, Zhu Q, Xu Z, Niu J Nutrients. 2024; 16(8).

PMID: 38674858 PMC: 11054788. DOI: 10.3390/nu16081167.

References

Yang M, Meng F, Gu W, Fu L, Zhang F, Li F . Influence of Polysaccharides From on Short-Chain Fatty Acid Production and Quorum Sensing in . Front Microbiol. 2021; 12:758870. PMC: 8635744. DOI: 10.3389/fmicb.2021.758870. View

Liu D, Chen Q, Miao Y, Li J, Deng X . First Report of Southern Blight on Polygonatum sibiricum Caused by Sclerotium delphinii in China. Plant Dis. 2021; . DOI: 10.1094/PDIS-10-20-2151-PDN. View

Zhao P, Li X, Wang Y, Zhang X, Jia H, Guo L . Comparative studies on characterization, saccharide mapping and antiglycation activity of polysaccharides from different Polygonatum ssp. J Pharm Biomed Anal. 2020; 186:113243. DOI: 10.1016/j.jpba.2020.113243. View

Forni C, Facchiano F, Bartoli M, Pieretti S, Facchiano A, DArcangelo D . Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases. Biomed Res Int. 2019; 2019:8748253. PMC: 6475554. DOI: 10.1155/2019/8748253. View

Borciani G, Montalbano G, Baldini N, Cerqueni G, Vitale-Brovarone C, Ciapetti G . Co-culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches. Acta Biomater. 2020; 108:22-45. DOI: 10.1016/j.actbio.2020.03.043. View

Hwang J, Yadav D, Lee P, Jin J . Immunomodulatory effects of polysaccharides from marine algae for treating cancer, infectious disease, and inflammation. Phytother Res. 2021; 36(2):761-777. DOI: 10.1002/ptr.7348. View

Li R, Chan W, Mat W, Ho Y, Yeung R, Tsang S . Antiaging and Anxiolytic Effects of Combinatory Formulas Based on Four Medicinal Herbs. Evid Based Complement Alternat Med. 2017; 2017:4624069. PMC: 5387814. DOI: 10.1155/2017/4624069. View

Zeng G, Zhang Z, Lu L, Xiao D, Xiong C, Zhao Y . Protective effects of Polygonatum sibiricum polysaccharide on ovariectomy-induced bone loss in rats. J Ethnopharmacol. 2011; 136(1):224-9. DOI: 10.1016/j.jep.2011.04.049. View

Wang J, Lu C, Liu D, Xu Y, Zhu Y, Wu H . Constituents from Polygonatum sibiricum and their inhibitions on the formation of advanced glycosylation end products. J Asian Nat Prod Res. 2016; 18(7):697-704. DOI: 10.1080/10286020.2015.1135905. View

10.

Solem S, Hagen R, Wang C, Hjemdal O, Waterloo K, Eisemann M . Metacognitions and Mindful Attention Awareness in Depression: A Comparison Of Currently Depressed, Previously Depressed and Never Depressed Individuals. Clin Psychol Psychother. 2015; 24(1):94-102. DOI: 10.1002/cpp.1983. View

11.

Zhao P, Zhao C, Li X, Gao Q, Huang L, Xiao P . The genus Polygonatum: A review of ethnopharmacology, phytochemistry and pharmacology. J Ethnopharmacol. 2017; 214:274-291. DOI: 10.1016/j.jep.2017.12.006. View

12.

He L, Yan B, Yao C, Chen X, Li L, Wu Y . Oligosaccharides from Polygonatum Cyrtonema Hua: Structural characterization and treatment of LPS-induced peritonitis in mice. Carbohydr Polym. 2021; 255:117392. DOI: 10.1016/j.carbpol.2020.117392. View

13.

Li J, Wang X, Zhou R, Cheng F, Tang X, Lao J . Hua Polysaccharides Protect BV2 Microglia Relief Oxidative Stress and Ferroptosis by Regulating NRF2/HO-1 Pathway. Molecules. 2022; 27(20). PMC: 9610736. DOI: 10.3390/molecules27207088. View

14.

Houben K, Jolie R, Fraeye I, Van Loey A, Hendrickx M . Comparative study of the cell wall composition of broccoli, carrot, and tomato: structural characterization of the extractable pectins and hemicelluloses. Carbohydr Res. 2011; 346(9):1105-11. DOI: 10.1016/j.carres.2011.04.014. View

15.

Chen J, Xu Y, Tan Z . CO-triggered switchable hydrophilicity solvent as a recyclable extractant for ultrasonic-assisted extraction of Polygonatum sibiricum polysaccharides. Food Chem. 2022; 402:134301. DOI: 10.1016/j.foodchem.2022.134301. View

16.

Longo V, Anderson R . Nutrition, longevity and disease: From molecular mechanisms to interventions. Cell. 2022; 185(9):1455-1470. PMC: 9089818. DOI: 10.1016/j.cell.2022.04.002. View

17.

Mao Y, Song Y, Pan S, Li N, Wang W, Feng B . Effect of Codonopsis Radix and Polygonati Rhizoma on the regulation of the IRS1/PI3K/AKT signaling pathway in type 2 diabetic mice. Front Endocrinol (Lausanne). 2023; 13:1068555. PMC: 9794842. DOI: 10.3389/fendo.2022.1068555. View

18.

Tang S, Mao X, Chen Y, Yan L, Ye L, Li S . Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death. Front Immunol. 2022; 13:870239. PMC: 9098816. DOI: 10.3389/fimmu.2022.870239. View

19.

Luo M, Hu Z, Zhong Z, Liu L, Lin C, He Q . Chemical Structures and Pharmacological Properties of Typical Bioflavonoids in (PGR). J Environ Public Health. 2022; 2022:4649614. PMC: 9788903. DOI: 10.1155/2022/4649614. View

20.

Shu G, Xu D, Zhao J, Yin L, Lin J, Fu H . Protective effect of Polygonatum sibiricum polysaccharide on cyclophosphamide-induced immunosuppression in chickens. Res Vet Sci. 2021; 135:96-105. DOI: 10.1016/j.rvsc.2020.12.025. View