Bifidobacterium Lactis Probio-M8 Regulates Gut Microbiota to Alleviate Alzheimer's Disease in the APP/PS1 Mouse Model

Overview

Journal Eur J Nutr

Specialty Nutritional Sciences

Date 2021 Apr 2

PMID 33796919

Citations 27

Authors

Jianing Cao

William Kwame Amakye

Chunli Qi

Xiaojun Liu

Jie Ma

Jiaoyan Ren

Affiliations

Soon will be listed here.

Abstract

Purpose: Studies have shown that Alzheimer's disease is associated with significant alterations in the gut microbiota. But the effect of probiotics and/or prebiotics on Alzheimer's disease still remains to be explored. The aim of this study was to determine whether Bifidobacterium Lactis Probio-M8 could alleviate Alzheimer's disease pathophysiologies in the APP/PS1 transgenic mouse model.

Methods: 4-month old APP/PS1 mice were randomly put into two groups and fed with either Probio-M8 or saline water for 45 days. Fecal samples of mice were collected at the beginning and the end of the treatment period to determine the composition of the gut microbiota via 16S ribosomal RNA sequencing technology. The number and size of Aβ plaques in the brain were quantified. In addition, Y maze, novel object recognition and nest building were employed to access cognitive function in the 8-months old APP/PS1 mice at the end of the treatment period.

Conclusion: Our results demonstrated that Probio-M8 reduced Aβ plaque burden in the whole brain and protected against gut microbiota dysbiosis. Furthermore, Probio-M8 could alleviate cognitive impairment in the APP/PS1 mouse.

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