Acupuncture Modulates the Gut Microbiota in Alzheimer's Disease: Current Evidence, Challenges, and Future Opportunities

Overview

Journal Front Neurosci

Date 2024 Mar 18

PMID 38495110

Authors

Long Yan

Hong Li

Yulin Qian

Qidi Liu

Shan Cong

Baomin Dou

Yu Wang

Meng Wang

Tao Yu

Affiliations

Soon will be listed here.

Abstract

Alzheimer's disease, one of the most severe and common neurodegenerative diseases, has no effective cure. Therefore it is crucial to explore novel and effective therapeutic targets. The gut microbiota - brain axis has been found to play a role in Alzheimer's disease by regulating the neuro-immune and endocrine systems. At the same time, acupuncture can modulate the gut microbiota and may impact the course of Alzheimer's disease. In this Review, we discuss recent studies on the role of acupuncture on the gut microbiota as well current challenges and future opportunities of acupuncture as potential treatment for the prevention and treatment of Alzheimer's disease.

Citing Articles

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References

Utton M, Noble W, Hill J, Anderton B, Hanger D . Molecular motors implicated in the axonal transport of tau and alpha-synuclein. J Cell Sci. 2005; 118(Pt 20):4645-54. DOI: 10.1242/jcs.02558. View

Wang X, Sun G, Feng T, Zhang J, Huang X, Wang T . Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression. Cell Res. 2019; 29(10):787-803. PMC: 6796854. DOI: 10.1038/s41422-019-0216-x. View

Vogt N, Kerby R, Dill-McFarland K, Harding S, Merluzzi A, Johnson S . Gut microbiome alterations in Alzheimer's disease. Sci Rep. 2017; 7(1):13537. PMC: 5648830. DOI: 10.1038/s41598-017-13601-y. View

Jiang J, Liu H, Wang Z, Tian H, Wang S, Yang J . Electroacupuncture could balance the gut microbiota and improve the learning and memory abilities of Alzheimer's disease animal model. PLoS One. 2021; 16(11):e0259530. PMC: 8575259. DOI: 10.1371/journal.pone.0259530. View

Liu C, Guo X, Chang X . Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A Systematic Review and Meta-analysis. Biomed Res Int. 2022; 2022:4806163. PMC: 9398783. DOI: 10.1155/2022/4806163. View

Li Y, Jiang J, Tang Q, Tian H, Wang S, Wang Z . Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model. Neural Plast. 2020; 2020:8867547. PMC: 7487106. DOI: 10.1155/2020/8867547. View

Du M, Luo H, Hu S, Lv Y, Lin Z, Ma L . Electroacupuncture improves gut barrier dysfunction in prolonged hemorrhagic shock rats through vagus anti-inflammatory mechanism. World J Gastroenterol. 2013; 19(36):5988-99. PMC: 3785620. DOI: 10.3748/wjg.v19.i36.5988. View

Yang N, Yang J, Ye Y, Huang J, Wang L, Wang Y . Electroacupuncture ameliorates intestinal inflammation by activating α7nAChR-mediated JAK2/STAT3 signaling pathway in postoperative ileus. Theranostics. 2021; 11(9):4078-4089. PMC: 7977469. DOI: 10.7150/thno.52574. View

Weagley J, Zaydman M, Venkatesh S, Sasaki Y, Damaraju N, Yenkin A . Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition. Cell Rep. 2022; 39(4):110738. PMC: 9092222. DOI: 10.1016/j.celrep.2022.110738. View

10.

Bravo J, Forsythe P, Chew M, Escaravage E, Savignac H, Dinan T . Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci U S A. 2011; 108(38):16050-5. PMC: 3179073. DOI: 10.1073/pnas.1102999108. View

11.

Zhan X, Stamova B, Sharp F . Lipopolysaccharide Associates with Amyloid Plaques, Neurons and Oligodendrocytes in Alzheimer's Disease Brain: A Review. Front Aging Neurosci. 2018; 10:42. PMC: 5827158. DOI: 10.3389/fnagi.2018.00042. View

12.

Alexandrov P, Zhai Y, Li W, Lukiw W . Lipopolysaccharide-stimulated, NF-kB-, miRNA-146a- and miRNA-155-mediated molecular-genetic communication between the human gastrointestinal tract microbiome and the brain. Folia Neuropathol. 2019; 57(3):211-219. DOI: 10.5114/fn.2019.88449. View

13.

Soriano S, Curry K, Wang Q, Chow E, Treangen T, Villapol S . Fecal Microbiota Transplantation Derived from Alzheimer's Disease Mice Worsens Brain Trauma Outcomes in Wild-Type Controls. Int J Mol Sci. 2022; 23(9). PMC: 9103830. DOI: 10.3390/ijms23094476. View

14.

Favero F, Barberis E, Gagliardi M, Espinoza S, Contu L, Gustincich S . A Metabologenomic approach reveals alterations in the gut microbiota of a mouse model of Alzheimer's disease. PLoS One. 2022; 17(8):e0273036. PMC: 9401139. DOI: 10.1371/journal.pone.0273036. View

15.

Kim C, Cha L, Sim M, Jung S, Chun W, Baik H . Probiotic Supplementation Improves Cognitive Function and Mood with Changes in Gut Microbiota in Community-Dwelling Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial. J Gerontol A Biol Sci Med Sci. 2020; 76(1):32-40. PMC: 7861012. DOI: 10.1093/gerona/glaa090. View

16.

Ivanov I, de Llanos Frutos R, Manel N, Yoshinaga K, Rifkin D, Sartor R . Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine. Cell Host Microbe. 2008; 4(4):337-49. PMC: 2597589. DOI: 10.1016/j.chom.2008.09.009. View

17.

Bai H, Gu R, Chen L, Qian Y, Yu M, Xu S . Electroacupuncture interventions alleviates myocardial ischemia reperfusion injury through regulating gut microbiota in rats. Microvasc Res. 2021; 138:104235. DOI: 10.1016/j.mvr.2021.104235. View

18.

Zhang J, Lin X, Zhou H, Chen Y, Xiao S, Jiao J . Electroacupuncture: a new approach to open the blood-brain barrier in rats recovering from middle cerebral artery occlusion. Acupunct Med. 2018; 36(6):377-385. PMC: 6287560. DOI: 10.1136/acupmed-2017-011496. View

19.

Shen H, Guan Q, Zhang X, Yuan C, Tan Z, Zhai L . New mechanism of neuroinflammation in Alzheimer's disease: The activation of NLRP3 inflammasome mediated by gut microbiota. Prog Neuropsychopharmacol Biol Psychiatry. 2020; 100:109884. DOI: 10.1016/j.pnpbp.2020.109884. View

20.

Zhang Y, Ding N, Hao X, Zhao J, Zhao Y, Li Y . Manual acupuncture benignly regulates blood-brain barrier disruption and reduces lipopolysaccharide loading and systemic inflammation, possibly by adjusting the gut microbiota. Front Aging Neurosci. 2022; 14:1018371. PMC: 9607933. DOI: 10.3389/fnagi.2022.1018371. View