Smart Contact Lens and Transparent Heat Patch for Remote Monitoring and Therapy of Chronic Ocular Surface Inflammation Using Mobiles

Overview

Journal Sci Adv

Specialties Biology
Science

Date 2021 Apr 1

PMID 33789904

Citations 28

Authors

Jiuk Jang

Joohee Kim

Haein Shin

Young-Geun Park

Byung Jun Joo

Hunkyu Seo

Jong-Eun Won

Dai Woo Kim

Chang Young Lee

Hong Kyun Kim

Jang-Ung Park

Affiliations

Soon will be listed here.

Abstract

Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.

Citing Articles

Smart Contact Lenses: Disease Monitoring and Treatment.

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Wearable Biodevices Based on Two-Dimensional Materials: From Flexible Sensors to Smart Integrated Systems.

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Wearable Electrochemical Biosensors for Advanced Healthcare Monitoring.

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Tear-Based Ocular Wearable Biosensors for Human Health Monitoring.

Rajan A, Vishnu J, Shankar B Biosensors (Basel). 2024; 14(10).

PMID: 39451696 PMC: 11506517. DOI: 10.3390/bios14100483.

Flexible Graphene Field-Effect Transistors and Their Application in Flexible Biomedical Sensing.

Sun M, Wang S, Liang Y, Wang C, Zhang Y, Liu H Nanomicro Lett. 2024; 17(1):34.

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