Ultra-conformal Drawn-on-skin Electronics for Multifunctional Motion Artifact-free Sensing and Point-of-care Treatment

Overview

Journal Nat Commun

Specialty Biology

Date 2020 Aug 1

PMID 32732934

Citations 43

Authors

Faheem Ershad

Anish Thukral

Jiping Yue

Phillip Comeaux

Yuntao Lu

Hyunseok Shim

Kyoseung Sim

Nam-In Kim

Zhoulyu Rao

Ross Guevara

Luis Contreras

Fengjiao Pan

Yongcao Zhang

Ying-Shi Guan

Pinyi Yang

Xu Wang

Peng Wang

Xiaoyang Wu

Cunjiang Yu

Affiliations

Soon will be listed here.

Abstract

An accurate extraction of physiological and physical signals from human skin is crucial for health monitoring, disease prevention, and treatment. Recent advances in wearable bioelectronics directly embedded to the epidermal surface are a promising solution for future epidermal sensing. However, the existing wearable bioelectronics are susceptible to motion artifacts as they lack proper adhesion and conformal interfacing with the skin during motion. Here, we present ultra-conformal, customizable, and deformable drawn-on-skin electronics, which is robust to motion due to strong adhesion and ultra-conformality of the electronic inks drawn directly on skin. Electronic inks, including conductors, semiconductors, and dielectrics, are drawn on-demand in a freeform manner to develop devices, such as transistors, strain sensors, temperature sensors, heaters, skin hydration sensors, and electrophysiological sensors. Electrophysiological signal monitoring during motion shows drawn-on-skin electronics' immunity to motion artifacts. Additionally, electrical stimulation based on drawn-on-skin electronics demonstrates accelerated healing of skin wounds.

Citing Articles

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References

Liu Y, Pharr M, Salvatore G . Lab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring. ACS Nano. 2017; 11(10):9614-9635. DOI: 10.1021/acsnano.7b04898. View

Kim J, Lee M, Shim H, Ghaffari R, Cho H, Son D . Stretchable silicon nanoribbon electronics for skin prosthesis. Nat Commun. 2014; 5:5747. DOI: 10.1038/ncomms6747. View

Zhang Y, Yan Z, Nan K, Xiao D, Liu Y, Luan H . A mechanically driven form of Kirigami as a route to 3D mesostructures in micro/nanomembranes. Proc Natl Acad Sci U S A. 2015; 112(38):11757-64. PMC: 4586832. DOI: 10.1073/pnas.1515602112. View

Xu S, Yan Z, Jang K, Huang W, Fu H, Kim J . Materials science. Assembly of micro/nanomaterials into complex, three-dimensional architectures by compressive buckling. Science. 2015; 347(6218):154-9. DOI: 10.1126/science.1260960. View

Jeong J, Kim M, Cheng H, Yeo W, Huang X, Liu Y . Capacitive epidermal electronics for electrically safe, long-term electrophysiological measurements. Adv Healthc Mater. 2013; 3(5):642-8. DOI: 10.1002/adhm.201300334. View

Someya T, Amagai M . Toward a new generation of smart skins. Nat Biotechnol. 2019; 37(4):382-388. DOI: 10.1038/s41587-019-0079-1. View

Williams N, Noyce S, Cardenas J, Catenacci M, Wiley B, Franklin A . Silver nanowire inks for direct-write electronic tattoo applications. Nanoscale. 2019; 11(30):14294-14302. PMC: 6689233. DOI: 10.1039/c9nr03378e. View

Zhu Z, Guo S, Hirdler T, Eide C, Fan X, Tolar J . 3D Printed Functional and Biological Materials on Moving Freeform Surfaces. Adv Mater. 2018; 30(23):e1707495. PMC: 6310159. DOI: 10.1002/adma.201707495. View

Son D, Lee J, Qiao S, Ghaffari R, Kim J, Lee J . Multifunctional wearable devices for diagnosis and therapy of movement disorders. Nat Nanotechnol. 2014; 9(5):397-404. DOI: 10.1038/nnano.2014.38. View

10.

Miyamoto A, Lee S, Cooray N, Lee S, Mori M, Matsuhisa N . Inflammation-free, gas-permeable, lightweight, stretchable on-skin electronics with nanomeshes. Nat Nanotechnol. 2017; 12(9):907-913. DOI: 10.1038/nnano.2017.125. View

11.

Kelly A, Hallam T, Backes C, Harvey A, Esmaeily A, Godwin I . All-printed thin-film transistors from networks of liquid-exfoliated nanosheets. Science. 2017; 356(6333):69-73. DOI: 10.1126/science.aal4062. View

12.

Xu H, Lv Y, Qiu D, Zhou Y, Zeng H, Chu Y . An ultra-stretchable, highly sensitive and biocompatible capacitive strain sensor from an ionic nanocomposite for on-skin monitoring. Nanoscale. 2019; 11(4):1570-1578. DOI: 10.1039/c8nr08589g. View

13.

Trung T, Ramasundaram S, Hwang B, Lee N . An All-Elastomeric Transparent and Stretchable Temperature Sensor for Body-Attachable Wearable Electronics. Adv Mater. 2015; 28(3):502-9. DOI: 10.1002/adma.201504441. View

14.

Hattori Y, Falgout L, Lee W, Jung S, Poon E, Lee J . Multifunctional skin-like electronics for quantitative, clinical monitoring of cutaneous wound healing. Adv Healthc Mater. 2014; 3(10):1597-607. PMC: 4177017. DOI: 10.1002/adhm.201400073. View

15.

Petrofsky J, Lawson D, Suh H, Rossi C, Zapata K, Broadwell E . The influence of local versus global heat on the healing of chronic wounds in patients with diabetes. Diabetes Technol Ther. 2007; 9(6):535-44. DOI: 10.1089/dia.2007.0231. View

16.

Bjorklund S, Ruzgas T, Nowacka A, Dahi I, Topgaard D, Sparr E . Skin membrane electrical impedance properties under the influence of a varying water gradient. Biophys J. 2013; 104(12):2639-50. PMC: 3686338. DOI: 10.1016/j.bpj.2013.05.008. View

17.

Javaid A, Ashouri H, Dorier A, Etemadi M, Heller J, Roy S . Quantifying and Reducing Motion Artifacts in Wearable Seismocardiogram Measurements During Walking to Assess Left Ventricular Health. IEEE Trans Biomed Eng. 2016; 64(6):1277-1286. PMC: 5444999. DOI: 10.1109/TBME.2016.2600945. View

18.

Abdoli-Eramaki M, Damecour C, Christenson J, Stevenson J . The effect of perspiration on the sEMG amplitude and power spectrum. J Electromyogr Kinesiol. 2012; 22(6):908-13. DOI: 10.1016/j.jelekin.2012.04.009. View

19.

Smith M . Rx for ECG monitoring artifact. Crit Care Nurse. 1984; 4(1):64-6. View

20.

Wiese S, Anheier P, Connemara R, Mollner A, Neils T, Kahn J . Electrocardiographic motion artifact versus electrode impedance. IEEE Trans Biomed Eng. 2005; 52(1):136-9. DOI: 10.1109/TBME.2004.836503. View