Self-organized Patterning of Cell Morphology Via Mechanosensitive Feedback

Overview

Journal Elife

Specialty Biology

Date 2021 Mar 26

PMID 33769281

Citations 20

Authors

Natalie A Dye

Marko Popovic

K Venkatesan Iyer

Jana F Fuhrmann

Romina Piscitello-Gomez

Suzanne Eaton

Frank Julicher

Affiliations

Soon will be listed here.

Abstract

Tissue organization is often characterized by specific patterns of cell morphology. How such patterns emerge in developing tissues is a fundamental open question. Here, we investigate the emergence of tissue-scale patterns of cell shape and mechanical tissue stress in the wing imaginal disc during larval development. Using quantitative analysis of the cellular dynamics, we reveal a pattern of radially oriented cell rearrangements that is coupled to the buildup of tangential cell elongation. Developing a laser ablation method, we map tissue stresses and extract key parameters of tissue mechanics. We present a continuum theory showing that this pattern of cell morphology and tissue stress can arise via self-organization of a mechanical feedback that couples cell polarity to active cell rearrangements. The predictions of this model are supported by knockdown of MyoVI, a component of mechanosensitive feedback. Our work reveals a mechanism for the emergence of cellular patterns in morphogenesis.

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