Quantitative Image Analysis for Tissue Biomarker Use: A White Paper From the Digital Pathology Association

Overview

Journal Appl Immunohistochem Mol Morphol

Specialties Biochemistry
Cell Biology
Molecular Biology

Date 2021 Mar 18

PMID 33734106

Citations 13

Authors

Haydee Lara

Zaibo Li

Esther Abels

Famke Aeffner

Marilyn M Bui

Ehab A ElGabry

Cleopatra Kozlowski

Michael C Montalto

Anil V Parwani

Mark D Zarella

Douglas Bowman

David Rimm

Liron Pantanowitz

Affiliations

Soon will be listed here.

Abstract

Tissue biomarkers have been of increasing utility for scientific research, diagnosing disease, and treatment response prediction. There has been a steady shift away from qualitative assessment toward providing more quantitative scores for these biomarkers. The application of quantitative image analysis has thus become an indispensable tool for in-depth tissue biomarker interrogation in these contexts. This white paper reviews current technologies being employed for quantitative image analysis, their application and pitfalls, regulatory framework demands, and guidelines established for promoting their safe adoption in clinical practice.

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