Aspirin As a Potential Geroprotector: Experimental Data and Clinical Evidence

Overview

Journal Adv Exp Med Biol

Specialties Biology
General Medicine

Date 2021 Mar 16

PMID 33725352

Citations 3

Authors

Oleh Lushchak

Veronika Piskovatska

Olha Strilbytska

Iryna Kindrat

Nadya Stefanyshyn

Alexander Koliada

Volodymyr Bubalo

Kenneth B Storey

Alexander Vaiserman

Affiliations

Soon will be listed here.

Abstract

Aging is a biological process with effects at the molecular, cellular, tissue, organ, system, and organismal levels and is characterized by decline in physical function and higher risks of age-related diseases. The use of anti-aging drugs for disease prevention has become a high priority for science and is a new biomedicine trend. Geroprotectors are compounds which slow aging and increase lifespan of the organism in question. The common painkiller aspirin, a member of the non-steroidal anti-inflammatory drug (NSAID) family, is one of the potential geroprotective agents. Aspirin is often used in treatment of mild to moderate pain. It has anti-inflammatory and anti-pyretic properties and acts as an inhibitor of cyclooxygenase which results in inhibition of prostaglandin. Acetylsalicylic acid as an active compound of aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. Aspirin has shown life-extending effects in numerous model organisms. This chapter reviews the evidence for clinical efficacy of aspirin including cardiovascular disease prevention, anti-cancer effects, and improvement of cognitive function. However, there are some limitations of these therapies, including the risk of excessive bleeding. We have also summarized numerous experimental and analytical data that support health and longevity benefits of aspirin treatment by affecting pro-longevity pathways.

Citing Articles

Inhibiting the Priming for Cancer in Li-Fraumeni Syndrome.

Pantziarka P, Blagden S Cancers (Basel). 2022; 14(7).

PMID: 35406393 PMC: 8997074. DOI: 10.3390/cancers14071621.

Curcumin Acetylsalicylate Extends the Lifespan of .

Zhou L, Liu J, Bu L, Liao D, Cheng S, Zheng X Molecules. 2021; 26(21).

PMID: 34771018 PMC: 8586958. DOI: 10.3390/molecules26216609.

Effects of anti-aging interventions on intestinal microbiota.

Du Y, Gao Y, Zeng B, Fan X, Yang D, Yang M Gut Microbes. 2021; 13(1):1994835.

PMID: 34743658 PMC: 8583001. DOI: 10.1080/19490976.2021.1994835.

References

Lushchak O, Strilbytska O, Piskovatska V, Storey K, Koliada A, Vaiserman A . The role of the TOR pathway in mediating the link between nutrition and longevity. Mech Ageing Dev. 2017; 164:127-138. DOI: 10.1016/j.mad.2017.03.005. View

Lushchak O, Strilbytska O, Yurkevych I, Vaiserman A, Storey K . Implications of amino acid sensing and dietary protein to the aging process. Exp Gerontol. 2018; 115:69-78. DOI: 10.1016/j.exger.2018.11.021. View

Vaiserman A, Lushchak O, Koliada A . Anti-aging pharmacology: Promises and pitfalls. Ageing Res Rev. 2016; 31:9-35. DOI: 10.1016/j.arr.2016.08.004. View

Vaiserman A, Lushchak O . Implementation of longevity-promoting supplements and medications in public health practice: achievements, challenges and future perspectives. J Transl Med. 2017; 15(1):160. PMC: 5520340. DOI: 10.1186/s12967-017-1259-8. View

Lushchak O, Strilbytska O, Koliada A, Zayachkivska A, Burdyliuk N, Yurkevych I . Nanodelivery of phytobioactive compounds for treating aging-associated disorders. Geroscience. 2019; 42(1):117-139. PMC: 7031473. DOI: 10.1007/s11357-019-00116-9. View

Piskovatska V, Stefanyshyn N, Storey K, Vaiserman A, Lushchak O . Metformin as a geroprotector: experimental and clinical evidence. Biogerontology. 2018; 20(1):33-48. DOI: 10.1007/s10522-018-9773-5. View

Vane J . Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol. 1971; 231(25):232-5. DOI: 10.1038/newbio231232a0. View

Ricciotti E, FitzGerald G . Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol. 2011; 31(5):986-1000. PMC: 3081099. DOI: 10.1161/ATVBAHA.110.207449. View

Smith W, Dewitt D, Garavito R . Cyclooxygenases: structural, cellular, and molecular biology. Annu Rev Biochem. 2000; 69:145-82. DOI: 10.1146/annurev.biochem.69.1.145. View

10.

Smyth E, Grosser T, Wang M, Yu Y, FitzGerald G . Prostanoids in health and disease. J Lipid Res. 2008; 50 Suppl:S423-8. PMC: 2674745. DOI: 10.1194/jlr.R800094-JLR200. View

11.

Loll P, Picot D, Garavito R . The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Nat Struct Biol. 1995; 2(8):637-43. DOI: 10.1038/nsb0895-637. View

12.

Chiang N, Serhan C . Aspirin triggers formation of anti-inflammatory mediators: New mechanism for an old drug. Discov Med. 2010; 4(24):470-5. View

13.

Awtry E, Loscalzo J . Aspirin. Circulation. 2000; 101(10):1206-18. DOI: 10.1161/01.cir.101.10.1206. View

14.

Bartels A, Leenders K . Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration. Curr Neuropharmacol. 2010; 8(1):62-8. PMC: 2866462. DOI: 10.2174/157015910790909485. View

15.

Fontana L, Partridge L, Longo V . Extending healthy life span--from yeast to humans. Science. 2010; 328(5976):321-6. PMC: 3607354. DOI: 10.1126/science.1172539. View

16.

Hayashi S, McMahon A . Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Dev Biol. 2002; 244(2):305-18. DOI: 10.1006/dbio.2002.0597. View

17.

Markaki M, Tavernarakis N . Modeling human diseases in Caenorhabditis elegans. Biotechnol J. 2010; 5(12):1261-76. DOI: 10.1002/biot.201000183. View

18.

Millburn G, Crosby M, Gramates L, Tweedie S . FlyBase portals to human disease research using Drosophila models. Dis Model Mech. 2016; 9(3):245-52. PMC: 4826978. DOI: 10.1242/dmm.023317. View

19.

Ugur B, Chen K, Bellen H . Drosophila tools and assays for the study of human diseases. Dis Model Mech. 2016; 9(3):235-44. PMC: 4833332. DOI: 10.1242/dmm.023762. View

20.

Ayyadevara S, Bharill P, Dandapat A, Hu C, Khaidakov M, Mitra S . Aspirin inhibits oxidant stress, reduces age-associated functional declines, and extends lifespan of Caenorhabditis elegans. Antioxid Redox Signal. 2012; 18(5):481-90. DOI: 10.1089/ars.2011.4151. View