Prospects of Germline Nuclear Transfer in Women With Diminished Ovarian Reserve

Overview

Journal Front Endocrinol (Lausanne)

Specialty Endocrinology

Date 2021 Mar 11

PMID 33692760

Citations 10

Authors

Antonia Christodoulaki

Annekatrien Boel

Maoxing Tang

Chloe De Roo

Dominic Stoop

Bjorn Heindryckx

Affiliations

Soon will be listed here.

Abstract

Diminished ovarian reserve (DOR) is associated with a reduced quantity and quality of the retrieved oocytes, usually leading to poor reproductive outcomes which remain a great challenge for assisted reproduction technology (ART). Women with DOR often have to seek for oocyte donation, precluding genetically related offspring. Germline nuclear transfer (NT) is a novel technology in ART that involves the transfer of the nuclear genome from an affected oocyte/zygote of the patient to the cytoplast of an enucleated donor oocyte/zygote. Therefore, it offers opportunities for the generation of genetically related embryos. Currently, although NT is clinically applied only in women with serious mitochondrial DNA disorders, this technology has also been proposed to overcome certain forms of female infertility, such as advanced maternal age and embryo developmental arrest. In this review, we are proposing the NT technology as a future treatment option for DOR patients. Strikingly, the application of different NT strategies will result in an increase of the total number of available reconstituted embryos for DOR patients.

Citing Articles

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