Epithelial-Mesenchymal Transition in Liver Fluke-Induced Cholangiocarcinoma

Overview

Journal Cancers (Basel)

Publisher MDPI

Specialty Oncology

Date 2021 Mar 6

PMID 33672838

Citations 6

Authors

Kanlayanee Sawanyawisuth

Goro Sashida

Guojun Sheng

Affiliations

Soon will be listed here.

Abstract

Cholangiocarcinoma (CCA) is the second most common type of hepatic cancer. In east and southeast Asia, intrahepatic CCA is caused predominantly by infection of and , two species of parasitic liver flukes. In this review, we present molecular evidence that liver fluke-associated CCAs have enhanced features of epithelial-mesenchymal transition (EMT) in bile duct epithelial cells (cholangiocytes) and that some of those features are associated with mis-regulation at the epigenetic level. We hypothesize that both direct and indirect mechanisms underlie parasitic infection-induced EMT in CCA.

Citing Articles

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