Chronic Tissue Inflammation and Metabolic Disease

Overview

Journal Genes Dev

Specialty Molecular Biology

Date 2021 Mar 2

PMID 33649162

Citations 108

Authors

Yun Sok Lee

Jerrold Olefsky

Affiliations

Soon will be listed here.

Abstract

Obesity is the most common cause of insulin resistance, and the current obesity epidemic is driving a parallel rise in the incidence of T2DM. It is now widely recognized that chronic, subacute tissue inflammation is a major etiologic component of the pathogenesis of insulin resistance and metabolic dysfunction in obesity. Here, we summarize recent advances in our understanding of immunometabolism. We discuss the characteristics of chronic inflammation in the major metabolic tissues and how obesity triggers these events, including a focus on the role of adipose tissue hypoxia and macrophage-derived exosomes. Last, we also review current and potential new therapeutic strategies based on immunomodulation.

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