Cardiac Extracellular Volume Fraction in Cats with Preclinical Hypertrophic Cardiomyopathy

Overview

Journal J Vet Intern Med

Specialties General Medicine
Veterinary Medicine

Date 2021 Feb 26

PMID 33634479

Citations 7

Authors

Ryan C Fries

Saki Kadotani

Stephanie C J Keating

Jonathan P Stack

Affiliations

Soon will be listed here.

Abstract

Background: Cardiac magnetic resonance imaging (CMR) allows for detection of fibrosis in hypertrophic cardiomyopathy (HCM) by quantification of the extracellular volume fraction (ECV).

Hypothesis/objectives: To quantify native T1 mapping and ECV in cats. We hypothesize that native T1 mapping and ECV will be significantly increased in HCM cats compared with healthy cats.

Animals: Seventeen healthy and 12 preclinical HCM, age-matched, client-owned cats.

Methods: Prospective observational study. Tests performed included indirect blood pressure, CBC, biochemical analysis including total thyroid, urinalysis, transthoracic echocardiogram, and CMR. Cats were considered healthy if all tests were within normal limits and a diagnosis of HCM was determined by the presence of left ventricular concentric hypertrophy ≥6 mm on echocardiography.

Results: There were statistically significant differences in LV mass (healthy = 5.87 g, HCM = 10.3 g, P < .0001), native T1 mapping (healthy = 1122 ms, HCM = 1209 ms, P = .004), and ECV (healthy = 26.0%, HCM = 32.6%, P < .0001). Variables of diastolic function including deceleration time of early diastolic transmitral flow (DTE), ratio between peak velocity of early diastolic transmitral flow and peak velocity of late diastolic transmitral flow (E : A), and peak velocity of late diastolic transmitral flow (A wave) were significantly correlated with ECV (DTE; r = 0.73 P = .007, E : A; r = -0.75 P = .004, A wave; r = 0.76 P = .004).

Conclusions And Clinical Importance: Quantitative assessment of cardiac ECV is feasible and can provide additional information not available using echocardiography.

Citing Articles

Extracellular Volume and Fibrosis Volume of Left Ventricular Myocardium Assessed by Cardiac Magnetic Resonance in Vaccinated and Unvaccinated Patients with a History of SARS-CoV-2 Infection.

Gac P, Hajdusianek W, Zorawik A, Poreba M, Poreba R Cardiovasc Toxicol. 2024; 24(12):1455-1466.

PMID: 39404974 PMC: 11564387. DOI: 10.1007/s12012-024-09929-3.

Importance of T1-Mapping Sequence in Patients with Hypertrophic Cardiomyopathy without Foci of Non-Ischemic Myocardial Injury in Late Gadolinium Enhancement Sequence.

Zdebik N, Poreba R, Gac P Biomedicines. 2024; 12(6).

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Aortic annular plane systolic excursion in cats with hypertrophic cardiomyopathy.

Dutton L, Spalla I, Seo J, Silva J, Novo Matos J J Vet Intern Med. 2023; 38(1):61-70.

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Exploration of Mediators Associated with Myocardial Remodelling in Feline Hypertrophic Cardiomyopathy.

Cheng W, Lawson C, Liu H, Wilkie L, Dobromylskyj M, Luis Fuentes V Animals (Basel). 2023; 13(13).

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Natural history of hypertrophic cardiomyopathy in cats from rehoming centers: The CatScan II study.

Novo Matos J, Payne J, Seo J, Luis Fuentes V J Vet Intern Med. 2022; 36(6):1900-1912.

PMID: 36315028 PMC: 9708425. DOI: 10.1111/jvim.16576.

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