» Articles » PMID: 3359448

Serum Uric Acid Unrelated to Cancer Incidence in Humans

Overview
Journal Cancer Res
Specialty Oncology
Date 1988 May 15
PMID 3359448
Citations 12
Authors
Affiliations
Soon will be listed here.
Abstract

We examined the hypothesis that low levels of serum uric acid are associated with elevated cancer risk. A subpopulation (163,830 members) of a large health maintenance organization was followed for a mean of 9.8 years after a multiphasic health checkup at which serum uric acid level was measured. Total cancer incidence as well as site-specific incidence (for lung, colon, and prostate cancer in men and lung, colon, breast, uterine, and cervical cancer in women) was ascertained from hospital discharge records and the Surveillance, Epidemiology and End Results program in the San Francisco-Oakland Bay area. Age-adjusted cancer incidence was not elevated in the lower deciles of serum uric acid level. After adjusting for age, race, education, smoking, alcohol consumption, and body mass, using proportional hazards models, the risk of cancer was not elevated at lower levels of uric acid. Our results suggest that if increased risk of cancer is associated with low serum uric acid, this risk is associated with serum uric levels below those commonly seen in human populations.

Citing Articles

U-shaped relationship between serum uric acid and gastric cancer risk: a large prospective cohort study.

Huang J, Mi N, Yang J, Zheng Y, Yuan J, Meng W Front Oncol. 2025; 14:1482814.

PMID: 39763609 PMC: 11700790. DOI: 10.3389/fonc.2024.1482814.


Role of Serum Uric Acid as a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study.

Manifar S, Rahimzamani A, Shirkhoda M, Ghamsari M, Bakhshi M Biomed Res Int. 2020; 2020:5185423.

PMID: 33005687 PMC: 7509556. DOI: 10.1155/2020/5185423.


Prognostic Significance of Serum Uric Acid and Gamma-Glutamyltransferase in Patients with Advanced Gastric Cancer.

Yang S, He X, Liu Y, Ding X, Jiang H, Tan Y Dis Markers. 2019; 2019:1415421.

PMID: 31885729 PMC: 6918938. DOI: 10.1155/2019/1415421.


Serum Urate, Genetic Variation, and Prostate Cancer Risk: Atherosclerosis Risk in Communities (ARIC) Study.

Wang A, Barber J, Tin A, De Marzo A, Kottgen A, Joshu C Cancer Epidemiol Biomarkers Prev. 2019; 28(7):1259-1261.

PMID: 31263056 PMC: 6608724. DOI: 10.1158/1055-9965.EPI-19-0161.


Albumin, bilirubin, uric acid and cancer risk: results from a prospective population-based study.

Kuhn T, Sookthai D, Graf M, Schubel R, Freisling H, Johnson T Br J Cancer. 2017; 117(10):1572-1579.

PMID: 28898231 PMC: 5680462. DOI: 10.1038/bjc.2017.313.