Role of Serum Uric Acid As a Protective Biomarker in Patients with Different Histopathological Grades of Oral Squamous Cell Carcinoma: a Case-Control Study

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2020 Oct 2

PMID 33005687

Citations 1

Authors

Soheila Manifar

Arezoo Rahimzamani

Mohammad Shirkhoda

Mohammad Nikkhah Ghamsari

Mahin Bakhshi

Affiliations

Soon will be listed here.

Abstract

The antioxidant properties of uric acid may have a protective effect against the formation of oxygen radicals and subsequently against carcinogenicity. The present study aimed at evaluating the serum level of uric acid in patients with oral squamous cell carcinoma (OSCC) with different histopathological grades. In this descriptive-analytical, case-control study, patients with OSCC and healthy controls were selected and matched regarding age and gender. The serum samples were collected from patients (before radiotherapy and chemotherapy) and controls, and their serum uric acid levels were measured enzymatically. Data were analyzed using independent -test and ANOVA at 0.05 level of significance. The mean serum uric acid level in OSCC patients (4.2 ± 1.5 mg/dL) and healthy controls (4.38 ± 1.22 mg/dL) was not significantly different ( = 0.377). No significant association was noted between the histopathological grade of OSCC and mean serum uric acid ( = 0.781). The serum uric acid level had a direct significant correlation with age in OSCC patients ( < 0.001). The results of this study did not support the role of uric acid as a protective biomarker in OSCC. Further prospective studies are recommended to better elucidate the role of uric acid in the etiology of OSCC.

Citing Articles

The Dual Effect of Abnormal Serum Uric Acid on Intervertebral Disc Degeneration.

Yang M, Wang N, Zhang W, Sun T, Zhang D, Chang Y Oxid Med Cell Longev. 2021; 2021:2362799.

PMID: 34630846 PMC: 8494577. DOI: 10.1155/2021/2362799.

References

Lawal A, Kolude B, Adeyemi B . Serum uric Acid levels in oral cancer patients seen at tertiary institution in Nigeria. Ann Ib Postgrad Med. 2014; 10(1):9-12. PMC: 4111041. View

Singh H, Shetty P, S V S, Patidar M . Analysis of salivary antioxidant levels in different clinical staging and histological grading of oral squamous cell carcinoma: noninvasive technique in dentistry. J Clin Diagn Res. 2014; 8(8):ZC08-11. PMC: 4190783. DOI: 10.7860/JCDR/2014/9119.4670. View

Robinson K, Morre J, Beckman J . Triuret: a novel product of peroxynitrite-mediated oxidation of urate. Arch Biochem Biophys. 2004; 423(1):213-7. DOI: 10.1016/j.abb.2003.10.011. View

Kandar R, Zakova P, Muzakova V . Monitoring of antioxidant properties of uric acid in humans for a consideration measuring of levels of allantoin in plasma by liquid chromatography. Clin Chim Acta. 2005; 365(1-2):249-56. DOI: 10.1016/j.cca.2005.09.002. View

Hiatt R, Fireman B . Serum uric acid unrelated to cancer incidence in humans. Cancer Res. 1988; 48(10):2916-8. View

Kittridge K, Willson R . Uric acid substantially enhances the free radical-induced inactivation of alcohol dehydrogenase. FEBS Lett. 1984; 170(1):162-4. DOI: 10.1016/0014-5793(84)81391-5. View

Ames B, Cathcart R, Schwiers E, Hochstein P . Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis. Proc Natl Acad Sci U S A. 1981; 78(11):6858-62. PMC: 349151. DOI: 10.1073/pnas.78.11.6858. View

Cristaldi M, Mauceri R, Di Fede O, Giuliana G, Campisi G, Panzarella V . Salivary Biomarkers for Oral Squamous Cell Carcinoma Diagnosis and Follow-Up: Current Status and Perspectives. Front Physiol. 2020; 10:1476. PMC: 6914830. DOI: 10.3389/fphys.2019.01476. View

Sadati Zarrini A, Moslemi D, Parsian H, Vessal M, Mosapour A, Kelagari Z . The status of antioxidants, malondialdehyde and some trace elements in serum of patients with breast cancer. Caspian J Intern Med. 2016; 7(1):31-6. PMC: 4761120. View

10.

Wagner V, Webber L, Curra M, Klein I, Meurer L, Carrad V . Bryne's grading system predicts poor disease-specific survival of oral squamous cell carcinoma: a comparative study among different histologic grading systems. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017; 123(6):688-696. DOI: 10.1016/j.oooo.2017.02.012. View

11.

Kolonel L, Yoshizawa C, Nomura A, STEMMERMANN G . Relationship of serum uric acid to cancer occurrence in a prospective male cohort. Cancer Epidemiol Biomarkers Prev. 1994; 3(3):225-8. View

12.

Giebultowicz J, Wroczynski P, Samolczyk-Wanyura D . Comparison of antioxidant enzymes activity and the concentration of uric acid in the saliva of patients with oral cavity cancer, odontogenic cysts and healthy subjects. J Oral Pathol Med. 2011; 40(9):726-30. DOI: 10.1111/j.1600-0714.2011.01045.x. View

13.

Khoubnasabjafari M, Ansarin K, Jouyban A . Salivary malondialdehyde as an oxidative stress biomarker in oral and systemic diseases. J Dent Res Dent Clin Dent Prospects. 2016; 10(2):71-4. PMC: 4945998. DOI: 10.15171/joddd.2016.011. View

14.

Yuan C, Xu X, Wang X, Xu L, Chen Z, Li Y . Relationship between serum uric acid and metastatic and nonmetastatic rectal cancer patients with undergoing no chemotherapy. Medicine (Baltimore). 2016; 95(47):e5463. PMC: 5134885. DOI: 10.1097/MD.0000000000005463. View

15.

Hsueh C, Shao M, Cao W, Li S, Zhou L . Pretreatment Serum Uric Acid as an Efficient Predictor of Prognosis in Men with Laryngeal Squamous Cell Cancer: A Retrospective Cohort Study. Oxid Med Cell Longev. 2019; 2019:1821969. PMC: 6501142. DOI: 10.1155/2019/1821969. View

16.

Kuzkaya N, Weissmann N, Harrison D, Dikalov S . Interactions of peroxynitrite with uric acid in the presence of ascorbate and thiols: implications for uncoupling endothelial nitric oxide synthase. Biochem Pharmacol. 2005; 70(3):343-54. DOI: 10.1016/j.bcp.2005.05.009. View

17.

Yiu A, Van Hemelrijck M, Garmo H, Holmberg L, Malmstrom H, Lambe M . Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study. Oncotarget. 2017; 8(26):42332-42342. PMC: 5522070. DOI: 10.18632/oncotarget.16198. View

18.

Bagnati M, Perugini C, Cau C, Bordone R, Albano E, Bellomo G . When and why a water-soluble antioxidant becomes pro-oxidant during copper-induced low-density lipoprotein oxidation: a study using uric acid. Biochem J. 1999; 340 ( Pt 1):143-52. PMC: 1220232. View

19.

Sanguinetti S, Batthyany C, Trostchansky A, Botti H, Lopez G, Wikinski R . Nitric oxide inhibits prooxidant actions of uric acid during copper-mediated LDL oxidation. Arch Biochem Biophys. 2004; 423(2):302-8. DOI: 10.1016/j.abb.2003.12.034. View

20.

Roi A, Rusu L, Roi C, Luca R, Boia S, Munteanu R . A New Approach for the Diagnosis of Systemic and Oral Diseases Based on Salivary Biomolecules. Dis Markers. 2019; 2019:8761860. PMC: 6398069. DOI: 10.1155/2019/8761860. View