CD8 T Lymphocytes: Crucial Players in Sjögren's Syndrome

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2021 Feb 15

PMID 33584670

Citations 39

Authors

Huimin Zhou

Jun Yang

Jie Tian

Shengjun Wang

Affiliations

Soon will be listed here.

Abstract

Primary Sjögren's syndrome (pSS) is a chronic autoimmune disease associated with damage to multiple organs and glands. The most common clinical manifestations are dry eyes, dry mouth, and enlarged salivary glands. Currently, CD4 T lymphocytes are considered to be key factors in the immunopathogenesis of pSS, but various studies have shown that CD8 T lymphocytes contribute to acinar injury in the exocrine glands. Therefore, in this review, we discussed the classification and features of CD8 T lymphocytes, specifically describing the role of CD8 T lymphocytes in disease pathophysiology. Furthermore, we presented treatment strategies targeting CD8 T cells to capitalize on the pathogenic and regulatory potential of CD8 T lymphocytes in SS to provide promising new strategies for this inflammatory disease.

Citing Articles

Lipid Metabolism: An Emerging Player in Sjögren's Syndrome.

Chang K, Luo P, Guo Z, Yang L, Pu J, Han F Clin Rev Allergy Immunol. 2025; 68(1):15.

PMID: 39934534 PMC: 11813826. DOI: 10.1007/s12016-025-09023-8.

A human oral commensal-mediated protection against Sjögren's syndrome with maintenance of T cell immune homeostasis and improved oral microbiota.

Tseng Y, Liao K, Lin W, Li C, Chang C, Hsu J NPJ Biofilms Microbiomes. 2025; 11(1):18.

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Immune and non-immune mediators in the fibrosis pathogenesis of salivary gland in Sjögren's syndrome.

Ma D, Feng Y, Lin X Front Immunol. 2024; 15:1421436.

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Single-Cell Transcriptomics Reveals a Pivotal Role of DOCK2 in Sjögren Disease.

Shen Y, Voigt A, Bhattacharyya I, Nguyen C ACR Open Rheumatol. 2024; 6(12):927-943.

PMID: 39382155 PMC: 11638132. DOI: 10.1002/acr2.11738.

Transactivation DNA-binding protein-related genes were associated with salivary gland injury in primary Sjögren syndrome.

Zhang N, Zhang H, Bao X, Yuan C Medicine (Baltimore). 2024; 103(39):e39827.

PMID: 39331939 PMC: 11441856. DOI: 10.1097/MD.0000000000039827.

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