Advances in Cellular and Molecular Pathways of Salivary Gland Damage in Sjögren's Syndrome

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2024 Jul 25

PMID 39050857

Authors

Wenxia Qi

Jiexiang Tian

Gang Wang

Yanfeng Yan

Tao Wang

Yong Wei

Zhandong Wang

Guohua Zhang

Yuanyuan Zhang

Jia Wang

Affiliations

Soon will be listed here.

Abstract

Sjögren's Syndrome (SS) is an autoimmune disorder characterized by dysfunction of exocrine glands. Primarily affected are the salivary glands, which exhibit the most frequent pathological changes. The pathogenesis involves susceptibility genes, non-genetic factors such as infections, immune cells-including T and B cells, macrophage, dendritic cells, and salivary gland epithelial cells. Inflammatory mediators such as autoantibodies, cytokines, and chemokines also play a critical role. Key signaling pathways activated include IFN, TLR, BAFF/BAFF-R, PI3K/Akt/mTOR, among others. Comprehensive understanding of these mechanisms is crucial for developing targeted therapeutic interventions. Thus, this study explores the cellular and molecular mechanisms underlying SS-related salivary gland damage, aiming to propose novel targeted therapeutic approaches.

Citing Articles

Updating on the Dual Role of Salivary Gland Epithelial Cell (SGEC) in Sjögren's Disease.

Zhu W, Lu Y, Zhu Y, Huang X, Wang Y J Inflamm Res. 2025; 18:3039-3053.

PMID: 40046682 PMC: 11881760. DOI: 10.2147/JIR.S509220.

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