Cell Type-specific MicroRNA Therapies for Myocardial Infarction

Overview

Journal Sci Transl Med

Specialties General Medicine
Science

Date 2021 Feb 11

PMID 33568517

Citations 15

Authors

Bohao Liu

Bryan Wang

Xiaokan Zhang

Roberta Lock

Trevor Nash

Gordana Vunjak-Novakovic

Affiliations

Soon will be listed here.

Abstract

Current interventions fail to recover injured myocardium after infarction and prompt the need for development of cardioprotective strategies. Of increasing interest is the therapeutic use of microRNAs to control gene expression through specific targeting of mRNAs. In this Review, we discuss current microRNA-based therapeutic strategies, describing the outcomes and limitations of key microRNAs with a focus on target cell types and molecular pathways. Last, we offer a perspective on the outlook of microRNA therapies for myocardial infarction, highlighting the outstanding challenges and emerging strategies.

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