Validation of Soy Isoflavone Intake and Its Health Effects: a Review of the Development of Exposure Biomarkers

Overview

Journal Nutr Res Pract

Specialty Nutritional Sciences

Date 2021 Feb 5

PMID 33542788

Citations 5

Authors

Hwan-Hee Jang

Young-Min Lee

Jeong-Sook Choe

Oran Kwon

Affiliations

Soon will be listed here.

Abstract

Background/objectives: It is difficult to consistently demonstrate the health effects of soy isoflavones owing to the multitude of factors contributing to their bioavailability. To accurately verify these health effects, dietary isoflavone intake should be measured using a biologically active dose rather than an intake dose. This concept has been expanded to the development of new exposure biomarkers in nutrition research. This review aims to provide an overview of the development of exposure biomarkers and suggest a novel research strategy for identifying the health effects of soy isoflavone intake.

Materials/methods: We cover recent studies on the health effects of soy isoflavones focusing on isoflavone metabolites as exposure biomarkers.

Results: Compared to non-fermented soy foods, fermented soy foods cause an increased concentration of isoflavones in the biofluid immediately following ingestion. The correlation between exposure biomarkers in blood and urine and the food frequency questionnaire was slightly lower than that of corresponding 24-h dietary recalls. Urinary and blood isoflavone levels did not show a consistent association with chronic disease and cancer risk.

Conclusion: It is crucial to understand the variable bioavailabilities of soy isoflavones, which may affect evaluations of soy isoflavone intake in health and disease. Further studies on the development of valid exposure biomarkers are needed to thoroughly investigate the health effects of isoflavone.

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References

Heald C, Bolton-Smith C, Ritchie M, Morton M, Alexander F . Phyto-oestrogen intake in Scottish men: use of serum to validate a self-administered food-frequency questionnaire in older men. Eur J Clin Nutr. 2005; 60(1):129-35. DOI: 10.1038/sj.ejcn.1602277. View

Lampe J . Isoflavonoid and lignan phytoestrogens as dietary biomarkers. J Nutr. 2003; 133 Suppl 3:956S-964S. DOI: 10.1093/jn/133.3.956S. View

Rienks J, Barbaresko J, Nothlings U . Association of isoflavone biomarkers with risk of chronic disease and mortality: a systematic review and meta-analysis of observational studies. Nutr Rev. 2017; 75(8):616-641. DOI: 10.1093/nutrit/nux021. View

Yonemoto-Yano H, Maebuchi M, Fukui K, Tsuzaki S, Takamatsu K, Uehara M . Malonyl isoflavone glucosides are chiefly hydrolyzed and absorbed in the colon. J Agric Food Chem. 2014; 62(10):2264-70. DOI: 10.1021/jf404378r. View

Tseng M, Olufade T, Kurzer M, Wahala K, Fang C, van der Schouw Y . Food frequency questionnaires and overnight urines are valid indicators of daidzein and genistein intake in U.S. women relative to multiple 24-h urine samples. Nutr Cancer. 2008; 60(5):619-26. DOI: 10.1080/01635580801993751. View

Setchell K . Absorption and metabolism of soy isoflavones-from food to dietary supplements and adults to infants. J Nutr. 2000; 130(3):654S-5S. DOI: 10.1093/jn/130.3.654S. View

Akbaraly T, Wurtz P, Singh-Manoux A, Shipley M, Haapakoski R, Lehto M . Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies. Sci Rep. 2018; 8(1):8620. PMC: 5988716. DOI: 10.1038/s41598-018-26441-1. View

Zhu Y, Wang P, Sha W, Sang S . Urinary Biomarkers of Whole Grain Wheat Intake Identified by Non-targeted and Targeted Metabolomics Approaches. Sci Rep. 2016; 6:36278. PMC: 5090248. DOI: 10.1038/srep36278. View

Morimoto Y, Beckford F, Franke A, Maskarinec G . Urinary isoflavonoid excretion as a biomarker of dietary soy intake during two randomized soy trials. Asia Pac J Clin Nutr. 2014; 23(2):205-9. PMC: 4227612. DOI: 10.6133/apjcn.2014.23.2.19. View

10.

Maruvada P, Lampe J, Wishart D, Barupal D, Chester D, Dodd D . Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches. Adv Nutr. 2019; 11(2):200-215. PMC: 7442414. DOI: 10.1093/advances/nmz075. View

11.

Zhang Y, Hendrich S, Murphy P . Glucuronides are the main isoflavone metabolites in women. J Nutr. 2003; 133(2):399-404. DOI: 10.1093/jn/133.2.399. View

12.

Zeng M, Sun R, Basu S, Ma Y, Ge S, Yin T . Disposition of flavonoids via recycling: Direct biliary excretion of enterically or extrahepatically derived flavonoid glucuronides. Mol Nutr Food Res. 2016; 60(5):1006-19. PMC: 5358014. DOI: 10.1002/mnfr.201500692. View

13.

French M, Thompson L, Hawker G . Validation of a phytoestrogen food frequency questionnaire with urinary concentrations of isoflavones and lignan metabolites in premenopausal women. J Am Coll Nutr. 2007; 26(1):76-82. DOI: 10.1080/07315724.2007.10719588. View

14.

Shi L, Brunius C, Bergdahl I, Johansson I, Rolandsson O, Donat Vargas C . Joint Analysis of Metabolite Markers of Fish Intake and Persistent Organic Pollutants in Relation to Type 2 Diabetes Risk in Swedish Adults. J Nutr. 2019; 149(8):1413-1423. DOI: 10.1093/jn/nxz068. View

15.

Whitton C, Ho J, Tay Z, Rebello S, Lu Y, Ong C . Relative Validity and Reproducibility of a Food Frequency Questionnaire for Assessing Dietary Intakes in a Multi-Ethnic Asian Population Using 24-h Dietary Recalls and Biomarkers. Nutrients. 2017; 9(10). PMC: 5691676. DOI: 10.3390/nu9101059. View

16.

Atkinson C, Skor H, Fitzgibbons E, Scholes D, Chen C, Wahala K . Overnight urinary isoflavone excretion in a population of women living in the United States, and its relationship to isoflavone intake. Cancer Epidemiol Biomarkers Prev. 2002; 11(3):253-60. View

17.

Setchell K . The history and basic science development of soy isoflavones. Menopause. 2017; 24(12):1338-1350. DOI: 10.1097/GME.0000000000001018. View

18.

Gao Q, Pratico G, Scalbert A, Vergeres G, Kolehmainen M, Manach C . A scheme for a flexible classification of dietary and health biomarkers. Genes Nutr. 2017; 12:34. PMC: 5728065. DOI: 10.1186/s12263-017-0587-x. View

19.

Loftfield E, Rothwell J, Sinha R, Keski-Rahkonen P, Robinot N, Albanes D . Prospective Investigation of Serum Metabolites, Coffee Drinking, Liver Cancer Incidence, and Liver Disease Mortality. J Natl Cancer Inst. 2019; 112(3):286-294. PMC: 7073908. DOI: 10.1093/jnci/djz122. View

20.

Ding M, Franke A, Rosner B, Giovannucci E, van Dam R, Tworoger S . Urinary isoflavonoids and risk of type 2 diabetes: a prospective investigation in US women. Br J Nutr. 2015; 114(10):1694-701. PMC: 4762594. DOI: 10.1017/S0007114515003359. View