Vitamin C Administration by Intravenous Infusion Increases Tumor Ascorbate Content in Patients With Colon Cancer: A Clinical Intervention Study

Overview

Journal Front Oncol

Specialty Oncology

Date 2021 Jan 28

PMID 33505915

Citations 11

Authors

Gabi U Dachs

Jamish Gandhi

Christina Wohlrab

Anitra C Carr

Helen R Morrin

Juliet M Pullar

Simone B Bayer

Tim W Eglinton

Bridget A Robinson

Margreet C M Vissers

Affiliations

Soon will be listed here.

Abstract

Clinical Trial Registration: ANZCTR Trial ID ACTRN12615001277538 (https://www.anzctr.org.au/).

Citing Articles

Role of Sodium-Dependent Vitamin C Transporter-2 and Ascorbate in Regulating the Hypoxic Pathway in Cultured Glioblastoma Cells.

Burgess E, Praditi C, Phillips E, Vissers M, Robinson B, Dachs G J Cell Biochem. 2024; 126(1):e30658.

PMID: 39382087 PMC: 11729540. DOI: 10.1002/jcb.30658.

Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.

Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, Allegra A Int J Mol Sci. 2024; 25(13).

PMID: 39000393 PMC: 11241675. DOI: 10.3390/ijms25137284.

Vitamin C intake and colorectal cancer survival according to KRAS and BRAF mutation: a prospective study in two US cohorts.

Shi S, Wang K, Ugai T, Giannakis M, Cazaubiel J, Chan A Br J Cancer. 2023; 129(11):1793-1800.

PMID: 37775523 PMC: 10667518. DOI: 10.1038/s41416-023-02452-2.

Association of Oral or Intravenous Vitamin C Supplementation with Mortality: A Systematic Review and Meta-Analysis.

Xu C, Yi T, Tan S, Xu H, Hu Y, Ma J Nutrients. 2023; 15(8).

PMID: 37111066 PMC: 10146309. DOI: 10.3390/nu15081848.

Overcoming EGFR Resistance in Metastatic Colorectal Cancer Using Vitamin C: A Review.

Machmouchi A, Chehade L, Temraz S, Shamseddine A Biomedicines. 2023; 11(3).

PMID: 36979659 PMC: 10045351. DOI: 10.3390/biomedicines11030678.

References

Campbell E, Vissers M, Wohlrab C, Hicks K, Strother R, Bozonet S . Pharmacokinetic and anti-cancer properties of high dose ascorbate in solid tumours of ascorbate-dependent mice. Free Radic Biol Med. 2016; 99:451-462. DOI: 10.1016/j.freeradbiomed.2016.08.027. View

Pearson J, Pullar J, Wilson R, Spittlehouse J, Vissers M, Skidmore P . Vitamin C Status Correlates with Markers of Metabolic and Cognitive Health in 50-Year-Olds: Findings of the CHALICE Cohort Study. Nutrients. 2017; 9(8). PMC: 5579624. DOI: 10.3390/nu9080831. View

Hoffer L, Levine M, Assouline S, Melnychuk D, Padayatty S, Rosadiuk K . Phase I clinical trial of i.v. ascorbic acid in advanced malignancy. Ann Oncol. 2008; 19(11):1969-74. DOI: 10.1093/annonc/mdn377. View

Guo X, Lu J, Wang Y, Gui Y, Duan X, Cai Z . Ascorbate antagonizes nickel ion to regulate JMJD1A expression in kidney cancer cells. Acta Biochim Biophys Sin (Shanghai). 2012; 44(4):330-8. DOI: 10.1093/abbs/gms004. View

Allen B, Bodeker K, Smith M, Monga V, Sandhu S, Hohl R . First-in-Human Phase I Clinical Trial of Pharmacologic Ascorbate Combined with Radiation and Temozolomide for Newly Diagnosed Glioblastoma. Clin Cancer Res. 2019; 25(22):6590-6597. PMC: 6858950. DOI: 10.1158/1078-0432.CCR-19-0594. View

Wohlrab C, Vissers M, Phillips E, Morrin H, Robinson B, Dachs G . The Association Between Ascorbate and the Hypoxia-Inducible Factors in Human Renal Cell Carcinoma Requires a Functional Von Hippel-Lindau Protein. Front Oncol. 2018; 8:574. PMC: 6284050. DOI: 10.3389/fonc.2018.00574. View

Padayatty S, Riordan H, Hewitt S, Katz A, Hoffer L, Levine M . Intravenously administered vitamin C as cancer therapy: three cases. CMAJ. 2006; 174(7):937-42. PMC: 1405876. DOI: 10.1503/cmaj.050346. View

Bergman B, Aaronson N, Ahmedzai S, Kaasa S, Sullivan M . The EORTC QLQ-LC13: a modular supplement to the EORTC Core Quality of Life Questionnaire (QLQ-C30) for use in lung cancer clinical trials. EORTC Study Group on Quality of Life. Eur J Cancer. 1994; 30A(5):635-42. DOI: 10.1016/0959-8049(94)90535-5. View

Pullar J, Dunham S, Dachs G, Vissers M, Carr A . Erythrocyte Ascorbate Is a Potential Indicator of Steady-State Plasma Ascorbate Concentrations in Healthy Non-Fasting Individuals. Nutrients. 2020; 12(2). PMC: 7071312. DOI: 10.3390/nu12020418. View

10.

Lykkesfeldt J, Tveden-Nyborg P . The Pharmacokinetics of Vitamin C. Nutrients. 2019; 11(10). PMC: 6835439. DOI: 10.3390/nu11102412. View

11.

Sage J, Carruthers A . Human erythrocytes transport dehydroascorbic acid and sugars using the same transporter complex. Am J Physiol Cell Physiol. 2014; 306(10):C910-7. PMC: 4024712. DOI: 10.1152/ajpcell.00044.2014. View

12.

Wohlrab C, Kuiper C, Vissers M, Phillips E, Robinson B, Dachs G . Ascorbate modulates the hypoxic pathway by increasing intracellular activity of the HIF hydroxylases in renal cell carcinoma cells. Hypoxia (Auckl). 2019; 7:17-31. PMC: 6527796. DOI: 10.2147/HP.S201643. View

13.

Cameron E, PAULING L . Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer. Proc Natl Acad Sci U S A. 1976; 73(10):3685-9. PMC: 431183. DOI: 10.1073/pnas.73.10.3685. View

14.

Jozwiak P, Krzeslak A, Wieczorek M, Lipinska A . Effect of Glucose on GLUT1-Dependent Intracellular Ascorbate Accumulation and Viability of Thyroid Cancer Cells. Nutr Cancer. 2015; 67(8):1333-41. DOI: 10.1080/01635581.2015.1078823. View

15.

Kuiper C, Molenaar I, Dachs G, Currie M, Sykes P, Vissers M . Low ascorbate levels are associated with increased hypoxia-inducible factor-1 activity and an aggressive tumor phenotype in endometrial cancer. Cancer Res. 2010; 70(14):5749-58. DOI: 10.1158/0008-5472.CAN-10-0263. View

16.

Lowndes N, Toh G . DNA repair: the importance of phosphorylating histone H2AX. Curr Biol. 2005; 15(3):R99-R102. DOI: 10.1016/j.cub.2005.01.029. View

17.

Cimmino L, Neel B, Aifantis I . Vitamin C in Stem Cell Reprogramming and Cancer. Trends Cell Biol. 2018; 28(9):698-708. PMC: 6102081. DOI: 10.1016/j.tcb.2018.04.001. View

18.

Chen Q, Espey M, Sun A, Pooput C, Kirk K, Krishna M . Pharmacologic doses of ascorbate act as a prooxidant and decrease growth of aggressive tumor xenografts in mice. Proc Natl Acad Sci U S A. 2008; 105(32):11105-9. PMC: 2516281. DOI: 10.1073/pnas.0804226105. View

19.

Camarena V, Wang G . The epigenetic role of vitamin C in health and disease. Cell Mol Life Sci. 2016; 73(8):1645-58. PMC: 4805483. DOI: 10.1007/s00018-016-2145-x. View

20.

Ma E, Chen P, Wilkins H, Wang T, Swerdlow R, Chen Q . Pharmacologic ascorbate induces neuroblastoma cell death by hydrogen peroxide mediated DNA damage and reduction in cancer cell glycolysis. Free Radic Biol Med. 2017; 113:36-47. PMC: 5856454. DOI: 10.1016/j.freeradbiomed.2017.09.008. View