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DNA Repair: the Importance of Phosphorylating Histone H2AX

Overview
Journal Curr Biol
Publisher Cell Press
Specialty Biology
Date 2005 Feb 8
PMID 15694301
Citations 99
Authors
Affiliations
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Abstract

How phosphorylated histone H2AX, known as gamma-H2AX, functions in the cellular response to DNA double-strand breaks is the subject of intensive investigation. Recent research in yeast and mammalian cells shows that gamma-H2AX facilitates post-replicational DNA repair by recruiting cohesin, a protein complex that holds sister chromatids together.

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