Microbiota, Epigenetics, and Trained Immunity. Convergent Drivers and Mediators of the Asthma Trajectory from Pregnancy to Childhood

Overview

Journal Am J Respir Crit Care Med

Specialty Critical Care

Date 2021 Jan 25

PMID 33493428

Citations 17

Authors

Susan V Lynch

Donata Vercelli

Affiliations

Soon will be listed here.

Citing Articles

Allergen-Specific Immunotherapy and Trained Immunity.

Martin-Cruz L, Palomares O Allergy. 2024; 80(3):677-689.

PMID: 39641571 PMC: 11891420. DOI: 10.1111/all.16423.

European Respiratory Society Research Seminar on Preventing Pediatric Asthma.

Grigg J, Barratt B, Bonnelykke K, Custovic A, Ege M, Pasquali C Pediatr Pulmonol. 2024; 60(1):e27401.

PMID: 39625247 PMC: 11748117. DOI: 10.1002/ppul.27401.

Indoor bioaerosols and asthma: Overview, implications, and mitigation strategies.

Dannemiller K, Conrad L, Haines S, Huang Y, Marr L, Siegel J J Allergy Clin Immunol. 2024; 155(3):714-725.

PMID: 39613110 PMC: 11875944. DOI: 10.1016/j.jaci.2024.11.027.

12,13-diHOME Promotes Inflammatory Macrophages and Epigenetically Modifies Their Capacity to Respond to Microbes and Allergens.

Lin D, Magnaye K, Porsche C, Levan S, Rackaityte E, Ozcam M J Immunol Res. 2024; 2024:2506586.

PMID: 38974097 PMC: 11227377. DOI: 10.1155/2024/2506586.

Gut microbiome in the first 1000 days and risk for childhood food allergy.

Davis E, Monaco C, Insel R, Jarvinen K Ann Allergy Asthma Immunol. 2024; 133(3):252-261.

PMID: 38494114 PMC: 11344696. DOI: 10.1016/j.anai.2024.03.010.

References

Carr T, Beamer P, Rothers J, Stern D, Gerald L, Rosales C . Prevalence of Asthma in School Children on the Arizona-Sonora Border. J Allergy Clin Immunol Pract. 2016; 5(1):114-120.e2. PMC: 5222738. DOI: 10.1016/j.jaip.2016.07.001. View

Fierer N, Nemergut D, Knight R, Craine J . Changes through time: integrating microorganisms into the study of succession. Res Microbiol. 2010; 161(8):635-42. DOI: 10.1016/j.resmic.2010.06.002. View

Holt P, Strickland D, Custovic A . Targeting maternal immune function during pregnancy for asthma prevention in offspring: Harnessing the "farm effect"?. J Allergy Clin Immunol. 2020; 146(2):270-272. DOI: 10.1016/j.jaci.2020.04.008. View

Dethlefsen L, Huse S, Sogin M, Relman D . The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol. 2008; 6(11):e280. PMC: 2586385. DOI: 10.1371/journal.pbio.0060280. View

Apostol A, Jensen K, Beaudin A . Training the Fetal Immune System Through Maternal Inflammation-A Layered Hygiene Hypothesis. Front Immunol. 2020; 11:123. PMC: 7026678. DOI: 10.3389/fimmu.2020.00123. View

Mawa P, Webb E, Filali-Mouhim A, Nkurunungi G, Sekaly R, Lule S . Maternal BCG scar is associated with increased infant proinflammatory immune responses. Vaccine. 2016; 35(2):273-282. PMC: 5357573. DOI: 10.1016/j.vaccine.2016.11.079. View

Fonseca W, Lucey K, Jang S, Fujimura K, Rasky A, Ting H . Lactobacillus johnsonii supplementation attenuates respiratory viral infection via metabolic reprogramming and immune cell modulation. Mucosal Immunol. 2017; 10(6):1569-1580. PMC: 5599307. DOI: 10.1038/mi.2017.13. View

Wang S, Ryan C, Boyaval P, Dempsey E, Ross R, Stanton C . Maternal Vertical Transmission Affecting Early-life Microbiota Development. Trends Microbiol. 2019; 28(1):28-45. DOI: 10.1016/j.tim.2019.07.010. View

Li J, Jia H, Cai X, Zhong H, Feng Q, Sunagawa S . An integrated catalog of reference genes in the human gut microbiome. Nat Biotechnol. 2014; 32(8):834-41. DOI: 10.1038/nbt.2942. View

10.

Purvis A, Hector A . Getting the measure of biodiversity. Nature. 2000; 405(6783):212-9. DOI: 10.1038/35012221. View

11.

Tanoue T, Atarashi K, Honda K . Development and maintenance of intestinal regulatory T cells. Nat Rev Immunol. 2016; 16(5):295-309. DOI: 10.1038/nri.2016.36. View

12.

Rothers J, Stern D, Lohman I, Spangenberg A, Wright A, DeVries A . Maternal Cytokine Profiles during Pregnancy Predict Asthma in Children of Mothers without Asthma. Am J Respir Cell Mol Biol. 2018; 59(5):592-600. PMC: 6236694. DOI: 10.1165/rcmb.2017-0410OC. View

13.

Nayfach S, Rodriguez-Mueller B, Garud N, Pollard K . An integrated metagenomics pipeline for strain profiling reveals novel patterns of bacterial transmission and biogeography. Genome Res. 2016; 26(11):1612-1625. PMC: 5088602. DOI: 10.1101/gr.201863.115. View

14.

Loss G, Bitter S, Wohlgensinger J, Frei R, Roduit C, Genuneit J . Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study. J Allergy Clin Immunol. 2012; 130(2):523-30.e9. DOI: 10.1016/j.jaci.2012.05.049. View

15.

Weissbrod O, Rothschild D, Barkan E, Segal E . Host genetics and microbiome associations through the lens of genome wide association studies. Curr Opin Microbiol. 2018; 44:9-19. DOI: 10.1016/j.mib.2018.05.003. View

16.

Merad M, Sathe P, Helft J, Miller J, Mortha A . The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting. Annu Rev Immunol. 2013; 31:563-604. PMC: 3853342. DOI: 10.1146/annurev-immunol-020711-074950. View

17.

Yona S, Kim K, Wolf Y, Mildner A, Varol D, Breker M . Fate mapping reveals origins and dynamics of monocytes and tissue macrophages under homeostasis. Immunity. 2013; 38(1):79-91. PMC: 3908543. DOI: 10.1016/j.immuni.2012.12.001. View

18.

Sharon G, Cruz N, Kang D, Gandal M, Wang B, Kim Y . Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 2019; 177(6):1600-1618.e17. PMC: 6993574. DOI: 10.1016/j.cell.2019.05.004. View

19.

Pfefferle P, Buchele G, Blumer N, Roponen M, Ege M, Krauss-Etschmann S . Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. J Allergy Clin Immunol. 2009; 125(1):108-15.e1-3. DOI: 10.1016/j.jaci.2009.09.019. View

20.

von Mutius E, Vercelli D . Farm living: effects on childhood asthma and allergy. Nat Rev Immunol. 2010; 10(12):861-8. DOI: 10.1038/nri2871. View