The Spleen: "epicenter" in Malaria Infection and Immunity

Overview

Journal J Leukoc Biol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2021 Jan 19

PMID 33464668

Citations 21

Authors

Debopam Ghosh

Jason S Stumhofer

Affiliations

Soon will be listed here.

Abstract

The spleen is a complex secondary lymphoid organ that plays a crucial role in controlling blood-stage infection with Plasmodium parasites. It is tasked with sensing and removing parasitized RBCs, erythropoiesis, the activation and differentiation of adaptive immune cells, and the development of protective immunity, all in the face of an intense inflammatory environment. This paper describes how these processes are regulated following infection and recognizes the gaps in our current knowledge, highlighting recent insights from human infections and mouse models.

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