-(coumarin-3-yl)cinnamamide Promotes Immunomodulatory, Neuroprotective, and Lung Function-Preserving Effects During Severe Malaria

Overview

Journal Pharmaceuticals (Basel)

Publisher MDPI

Specialty Chemistry

Date 2024 Jan 23

PMID 38256880

Authors

Paulo Gaio

Allysson Cramer

Natalia Fernanda de Melo Oliveira

Samuel Porto

Lucas Kramer

Rayane Aparecida Nonato Rabelo

Rafaela das Dores Pereira

Laura Lis de Oliveira Santos

Cesar Luis Nascimento Barbosa

Fabricio Marcus Silva Oliveira

Mauro Martins Teixeira

Remo Castro Russo

Maria Joao Matos

Fabiana Simao Machado

Affiliations

Soon will be listed here.

Abstract

ANKA (PbA) infection in mice resembles several aspects of severe malaria in humans, such as cerebral malaria and acute respiratory distress syndrome. Herein, the effects of -(coumarin-3-yl)cinnamamide (M220) against severe experimental malaria have been investigated. Treatment with M220 proved to protect cognitive abilities and lung function in PbA-infected mice, observed by an object recognition test and spirometry, respectively. In addition, treated mice demonstrated decreased levels of brain and lung inflammation. The production and accumulation of microglia, and immune cells that produce the inflammatory cytokines TNF and IFN-γ, decreased, while the production of the anti-inflammatory cytokine IL-10 by innate and adaptive immune cells was enhanced. Treatment with M220 promotes immunomodulatory, neuroprotective, and lung function-preserving effects during experimental severe malaria. Therefore, it may be an interesting therapeutic candidate to treat severe malaria effects.

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